Skip to content
DraconiticResearch
Search Sources API
203,203 studies31 sourcesUpdated 15 min ago
PreprintCC BY 4.0Genes & Development

Chromosomal requirements for formation of multivalent human nucleoli

  • Krystyna Giemza1
  • Hazel Mangan1
  • Brian McStay1
  1. 1Centre for Chromosome Biology, College of Science and Engineering, University of Galway, Galway H91 W2TY, Ireland
Read full textPDFDOICite

Abstract

Human nucleoli are multivalent, involving contributions from up to 10 NOR-bearing acrocentric chromosome p-arms. Precision megabase-scale chromosome engineering defines the requirements for this major genome organizational event. NOR deletions reveal that p-arm clustering can occur independent of rDNA. Deletion of all NOR-distal or NOR-proximal sequences individually have only a marginal effect on nucleolar association. Finally, deletion of an entire p-arm, while leaving centromere function intact, destroys the nucleolar association potential of that acrocentric. We propose that formation of multivalent nucleoli is not a nucleolar fusion event per se; rather it is driven by the surrounding chromosomal context of NORs.

Related

  1. The role of chromosomal inversions in local adaptation and ecotype formation across a variable landscape in an intertidal snail
    J. Reeve, O. Ortega-Martinez, P. Bergström +3
    bioRxivPreprintCC BY-NCFull textEvolutionary biologybioRxiv
  2. Cytokine-Mediated Plasticity in the Molecular Requirements for Peptide-Loading Complex Formation and Antigen Presentation
    Ritchlynn Aranha, Mohadeseh Dastpeyman, Kirti Pandey +4
    CellsPeer-reviewedCC BY 4.0Full textImmunologyCrossrefEurope PMC
  3. Recurrent mitotic error and purifying selection shape chromosomal mosaicism across human tissues
    D. Tang, N. Kamitaki, Y. Si +6
    bioRxivPreprintCC BY-NC-NDFull textGenetics & genomicsbioRxiv
  4. Sex Differences in Human Subcortical Anatomy are Robust and Replicable in Adulthood, Already Evident Prepubertally, and Aligned with Sex Chromosomal and Gonadal Influences
    H. M. Lee, S. Liu, F. Lalonde +11
    bioRxivPreprintCC BY-NC-NDFull textNeurosciencebioRxiv
  5. High quality chromosomal genome assemblies of three human Plasmodium species directly from natural infections
    Sunil Kumar Dogga, Jesse C. Rop, Alex Makunin +13
    PLOS PathogensPeer-reviewedCC BY 4.0Full textBioinformatics & computational biologyCell biologyPLOS

Cite

BibTeXRIS
BibTeX
@misc{giemza2026chromosomal,
  title = {{Chromosomal requirements for formation of multivalent human nucleoli}},
  author = {Krystyna Giemza and Hazel Mangan and Brian McStay},
  howpublished = {Genes \& Development},
  year = {2026},
  month = nov,
  doi = {10.1101/gad.354012.126},
  url = {https://doi.org/10.1101/gad.354012.126},
  note = {CC BY 4.0},
}
RIS
TY  - UNPB
TI  - Chromosomal requirements for formation of multivalent human nucleoli
AU  - Krystyna Giemza
AU  - Hazel Mangan
AU  - Brian McStay
PY  - 2026
DA  - 2026/11/01
PB  - Genes & Development
DO  - 10.1101/gad.354012.126
UR  - https://doi.org/10.1101/gad.354012.126
AB  - Human nucleoli are multivalent, involving contributions from up to 10 NOR-bearing acrocentric chromosome p-arms. Precision megabase-scale chromosome engineering defines the requirements for this major genome organizational event. NOR deletions reveal that p-arm clustering can occur independent of rDNA. Deletion of all NOR-distal or NOR-proximal sequences individually have only a marginal effect on nucleolar association. Finally, deletion of an entire p-arm, while leaving centromere function intact, destroys the nucleolar association potential of that acrocentric. We propose that formation of multivalent nucleoli is not a nucleolar fusion event per se; rather it is driven by the surrounding chromosomal context of NORs.
SN  - 0890-9369
SN  - 1549-5477
ER  -