Genome-wide association study of patterns of perinatal exposure to polyunsaturated fatty acids from the EDEN mother-child cohort
Abstract
The genetic determinants of polyunsaturated fatty acid (PUFA) status during the perinatal window require deeper understanding. We conducted a genome-wide association study of perinatal PUFA patterns in 1352 mother-child pairs from the French EDEN cohort using maternal genotype data. Five perinatal PUFA patterns had been previously derived using PUFA levels measured in maternal blood, cord blood, and colostrum simultaneously. We used linear regression models assuming additive genetic effects to assess the associations between common SNPs and each pattern, adjusting for maternal age, study center, and genetic ancestry. Pattern 1 “High omega-3 Long-chain (LC)-PUFAs, low omega-6 LC-PUFAs” was not associated with any genetic variants. Patterns 2 to 5—“Omega-6 LC-PUFAs,” “Colostrum LC-PUFAs,” “Omega-6 precursor (LA) and DGLA,” and “LA and colostrum ALA”—were strongly associated with variants in the FADS gene cluster. The strongest association was observed between Pattern 4 “Omega-6 precursor (LA) and DGLA,” and rs174546 located on FADS1 gene region (β (SE) = 0.80 (0.034), p < 10⁻102). No other robust association was found with other genes. These findings underscore the main contribution of FADS variants to the variability of four specific perinatal PUFA patterns in our cohort. This study should be replicated in larger, ancestrally diverse populations beyond individuals of European descent.
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BibTeX
@article{assi2026genomewide,
title = {{Genome-wide association study of patterns of perinatal exposure to polyunsaturated fatty acids from the EDEN mother-child cohort}},
author = {Aline Abou Assi and Manon Muntaner and Jonathan Y. Bernard and Martine Armand and Catherine Sarté and Muriel Tafflet and Marie-Aline Charles and Jean-François Deleuze and Aline Meirhaeghe and Barbara Heude},
journal = {Prostaglandins, Leukotrienes and Essential Fatty Acids},
year = {2026},
month = sep,
doi = {10.1016/j.plefa.2026.102777},
url = {https://inserm.hal.science/inserm-05752730v1},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Genome-wide association study of patterns of perinatal exposure to polyunsaturated fatty acids from the EDEN mother-child cohort
AU - Aline Abou Assi
AU - Manon Muntaner
AU - Jonathan Y. Bernard
AU - Martine Armand
AU - Catherine Sarté
AU - Muriel Tafflet
AU - Marie-Aline Charles
AU - Jean-François Deleuze
AU - Aline Meirhaeghe
AU - Barbara Heude
PY - 2026
DA - 2026/09/17
JO - Prostaglandins, Leukotrienes and Essential Fatty Acids
DO - 10.1016/j.plefa.2026.102777
UR - https://inserm.hal.science/inserm-05752730v1
AB - The genetic determinants of polyunsaturated fatty acid (PUFA) status during the perinatal window require deeper understanding. We conducted a genome-wide association study of perinatal PUFA patterns in 1352 mother-child pairs from the French EDEN cohort using maternal genotype data. Five perinatal PUFA patterns had been previously derived using PUFA levels measured in maternal blood, cord blood, and colostrum simultaneously. We used linear regression models assuming additive genetic effects to assess the associations between common SNPs and each pattern, adjusting for maternal age, study center, and genetic ancestry. Pattern 1 “High omega-3 Long-chain (LC)-PUFAs, low omega-6 LC-PUFAs” was not associated with any genetic variants. Patterns 2 to 5—“Omega-6 LC-PUFAs,” “Colostrum LC-PUFAs,” “Omega-6 precursor (LA) and DGLA,” and “LA and colostrum ALA”—were strongly associated with variants in the FADS gene cluster. The strongest association was observed between Pattern 4 “Omega-6 precursor (LA) and DGLA,” and rs174546 located on FADS1 gene region (β (SE) = 0.80 (0.034), p < 10⁻102). No other robust association was found with other genes. These findings underscore the main contribution of FADS variants to the variability of four specific perinatal PUFA patterns in our cohort. This study should be replicated in larger, ancestrally diverse populations beyond individuals of European descent.
SN - 0952-3278
ER -