Tension reduction from inter-membrane counter-deformation accelerates nuclear electroporation.
- 1School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China.
Abstract
Pulsed electric field ablation is an emerging non-thermal modality for tumor treatment, in which electroporation of both the plasma membrane and the nuclear envelope plays a critical role in inducing irreversible cellular damage. To elucidate the different effects of nanosecond pulsed electric fields (nsPEFs) on these membranes, we compared the electroporation responses of the single and double membranes under the same field strength employing molecular dynamics (MD) simulations. Our results demonstrate that the double membrane underwent faster electroporation, attributed to inter-membrane counter-deformation under Coulomb force, which modulated the local electric field direction and reduced membrane tension. Compared to the single membrane, the double membrane may be more susceptible to damage induced by nsPEFs. This finding may provide a molecular-scale theoretical reference for understanding the electroporation mechanism of the nuclear envelope relative to the plasma membrane under nsPEFs.
Related
- EpCAM-dependent membrane mechanics regulate nuclear deformation and promote gastric cancer metastasis
- Patterned membrane recycling balances apical and lateral cell surfaces to confine tissue deformation under stretch
- Integrative multi-omics analysis reveals a membrane tension signature associated with tumor-stroma crosstalk in hepatocellular carcinoma
- Pressure-induced membrane tension mechanically opens the germinant receptor GerA ion channel to trigger bacterial spore germination
- Membrane tension and cell–nucleus mechanical coupling regulate confined cell migration
BibTeX
@article{diao2026tension,
title = {{Tension reduction from inter-membrane counter-deformation accelerates nuclear electroporation.}},
author = {Yuepeng Diao and Ping Ye and Baolin Liu},
journal = {PloS one},
year = {2026},
month = oct,
doi = {10.1371/journal.pone.0361048},
url = {https://europepmc.org/article/MED/42912793},
note = {CC BY},
}
RIS
TY - JOUR
TI - Tension reduction from inter-membrane counter-deformation accelerates nuclear electroporation.
AU - Yuepeng Diao
AU - Ping Ye
AU - Baolin Liu
PY - 2026
DA - 2026/10/23
JO - PloS one
DO - 10.1371/journal.pone.0361048
UR - https://europepmc.org/article/MED/42912793
AB - Pulsed electric field ablation is an emerging non-thermal modality for tumor treatment, in which electroporation of both the plasma membrane and the nuclear envelope plays a critical role in inducing irreversible cellular damage. To elucidate the different effects of nanosecond pulsed electric fields (nsPEFs) on these membranes, we compared the electroporation responses of the single and double membranes under the same field strength employing molecular dynamics (MD) simulations. Our results demonstrate that the double membrane underwent faster electroporation, attributed to inter-membrane counter-deformation under Coulomb force, which modulated the local electric field direction and reduced membrane tension. Compared to the single membrane, the double membrane may be more susceptible to damage induced by nsPEFs. This finding may provide a molecular-scale theoretical reference for understanding the electroporation mechanism of the nuclear envelope relative to the plasma membrane under nsPEFs.
SN - 1932-6203
ER -