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PreprintCC BY-NC-ND 4.0arXiv

BOLD PSF: Impact of k-space trajectories and timing on the depiction of T2* contrast

  • Maria Engel
  • Lars Kasper
  • Klaas P Pruessmann
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Abstract

The timing of BOLD-fMRI is typically chosen such that TE matches T2*. This assumes contrast being exclusively elicited by signal differences at TE. While sensible for short or TE-symmetric readouts, such as EPIs, it oversimplifies contrast generation for longer or TE-asymmetric trajectories, such as spirals. We propose the concept of a BOLD PSF for a more comprehensive perspective on the imaging characteristics of a functional experiment. Our findings indicate that TE can be reduced for spiral-out without sacrificing BOLD-sensitivity when compared to EPI. Furthermore, we characterize the intrinsic trade-off between specificity and resolution of the BOLD response under varying TE.

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Cite

BibTeXRIS
BibTeX
@misc{engel2026bold,
  title = {{BOLD PSF: Impact of k-space trajectories and timing on the depiction of T2* contrast}},
  author = {Maria Engel and Lars Kasper and Klaas P Pruessmann},
  howpublished = {arXiv},
  year = {2026},
  month = oct,
  doi = {10.48550/arxiv.2610.15524},
  eprint = {2610.15524},
  archivePrefix = {arXiv},
  url = {https://arxiv.org/abs/2610.15524},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - UNPB
TI  - BOLD PSF: Impact of k-space trajectories and timing on the depiction of T2* contrast
AU  - Maria Engel
AU  - Lars Kasper
AU  - Klaas P Pruessmann
PY  - 2026
DA  - 2026/10/11
PB  - arXiv
DO  - 10.48550/arxiv.2610.15524
UR  - https://arxiv.org/abs/2610.15524
AB  - The timing of BOLD-fMRI is typically chosen such that TE matches T2*. This assumes contrast being exclusively elicited by signal differences at TE. While sensible for short or TE-symmetric readouts, such as EPIs, it oversimplifies contrast generation for longer or TE-asymmetric trajectories, such as spirals. We propose the concept of a BOLD PSF for a more comprehensive perspective on the imaging characteristics of a functional experiment. Our findings indicate that TE can be reduced for spiral-out without sacrificing BOLD-sensitivity when compared to EPI. Furthermore, we characterize the intrinsic trade-off between specificity and resolution of the BOLD response under varying TE.
ER  -