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Peer-reviewedCC BY 4.0PLOS One

Concurrent TMS-EEG to characterise interhemispheric signal propagation over the motor and prefrontal regions: An independent replication of GABAB receptor mechanisms

  • Jie Zhou1
  • Yiting He2
  • Chenxia Jin
  • Chen Yang
  • Yazhen Han
  • Yujun Wang
  • Zhen Zhen
  • Zhimin Huang
  • Shuyan Shi
  • Xianwei Che
  • Jiqing He
  1. 1Centre for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China
  2. 2Department of Obstetrics, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China
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Abstract

Callosal abnormalities disrupt interhemispheric communications that impair the recovery of a series of neurological and psychiatric disorders. Understanding interhemispheric communication could help identify treatments for disorders with dysfunctional callosal transmission. This study aimed to validate the sensitivity of a TMS-EEG-based measure of interhemispheric signal propagation (ISP) to GABAB receptor modulation, while independently replicating the pharmacological mechanisms of interhemispheric inhibition. A group of 29 participants received an oral dose of either baclofen, a GABAB receptor agonist, or a placebo. Before and after drug intake, single-pulse TMS-EEG was applied to assess ISP in both the motor and prefrontal regions. Our findings indicated that baclofen increased interhemispheric inhibition over the motor region, indexed by significantly decreased ISP (p = 0.037). No significant effect was observed in the dorsolateral prefrontal region (p = 0.186), suggesting regional specificity in GABAB receptor modulation of ISP. These findings uncovered the pharmacological mechanisms of interhemispheric inhibition as indexed by ISP. They also highlight the potential of ISP for characterising interhemispheric communication, which could inform the treatment for a series of disorders with dysfunctional callosal transmission.

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Cite

BibTeXRIS
BibTeX
@article{zhou2026concurrent,
  title = {{Concurrent TMS-EEG to characterise interhemispheric signal propagation over the motor and prefrontal regions: An independent replication of GABAB receptor mechanisms}},
  author = {Jie Zhou and Yiting He and Chenxia Jin and Chen Yang and Yazhen Han and Yujun Wang and Zhen Zhen and Zhimin Huang and Shuyan Shi and Xianwei Che and Jiqing He},
  journal = {PLOS One},
  year = {2026},
  month = oct,
  doi = {10.1371/journal.pone.0360250},
  url = {https://doi.org/10.1371/journal.pone.0360250},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Concurrent TMS-EEG to characterise interhemispheric signal propagation over the motor and prefrontal regions: An independent replication of GABAB receptor mechanisms
AU  - Jie Zhou
AU  - Yiting He
AU  - Chenxia Jin
AU  - Chen Yang
AU  - Yazhen Han
AU  - Yujun Wang
AU  - Zhen Zhen
AU  - Zhimin Huang
AU  - Shuyan Shi
AU  - Xianwei Che
AU  - Jiqing He
PY  - 2026
DA  - 2026/10/16
JO  - PLOS One
DO  - 10.1371/journal.pone.0360250
UR  - https://doi.org/10.1371/journal.pone.0360250
AB  - Callosal abnormalities disrupt interhemispheric communications that impair the recovery of a series of neurological and psychiatric disorders. Understanding interhemispheric communication could help identify treatments for disorders with dysfunctional callosal transmission. This study aimed to validate the sensitivity of a TMS-EEG-based measure of interhemispheric signal propagation (ISP) to GABAB receptor modulation, while independently replicating the pharmacological mechanisms of interhemispheric inhibition. A group of 29 participants received an oral dose of either baclofen, a GABAB receptor agonist, or a placebo. Before and after drug intake, single-pulse TMS-EEG was applied to assess ISP in both the motor and prefrontal regions. Our findings indicated that baclofen increased interhemispheric inhibition over the motor region, indexed by significantly decreased ISP (p = 0.037). No significant effect was observed in the dorsolateral prefrontal region (p = 0.186), suggesting regional specificity in GABAB receptor modulation of ISP. These findings uncovered the pharmacological mechanisms of interhemispheric inhibition as indexed by ISP. They also highlight the potential of ISP for characterising interhemispheric communication, which could inform the treatment for a series of disorders with dysfunctional callosal transmission.
SN  - 1932-6203
ER  -