Comparative immunogenicity of several inactivated influenza vaccines among healthcare workers in Hong Kong
- 1The University of Hong Kong
Abstract
We compared the immunogenicity of three licensed egg-based inactivated influenza vaccines, including TetrAnflu (Sinovac quadrivalent), Fluarix Tetra (GSK quadrivalent), and Vaxigrip (Sanofi trivalent), in adult healthcare workers in Hong Kong during the 2025/26 season. Age- and sex-matched recipients (n=30-40 per group) with paired pre- and post-vaccination sera were identified from an ongoing cohort. Hemagglutination-inhibition assays were performed against the egg-propagated 2025/26 vaccine reference strains. The three vaccines induced broadly comparable geometric mean fold-rises, post-vaccination geometric mean titers, proportions achieving titers >=40, and seroconversion rates against vaccine strains. These real-world data support the interchangeability of the three products for seasonal influenza vaccination programs among healthcare workers.
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BibTeX
@misc{lim2026comparative,
title = {{Comparative immunogenicity of several inactivated influenza vaccines among healthcare workers in Hong Kong}},
author = {W. W. Lim and L. Touyon and L. Mak and Y. C. Lau and S. M. S. Cheng and D. K. M. Ip and M. Peiris and B. J. Cowling and S.-S. Wong},
howpublished = {medRxiv},
year = {2026},
month = aug,
doi = {10.64898/2026.08.19.26360857},
url = {https://www.medrxiv.org/content/10.64898/2026.08.19.26360857v2},
note = {CC BY},
}
RIS
TY - UNPB
TI - Comparative immunogenicity of several inactivated influenza vaccines among healthcare workers in Hong Kong
AU - W. W. Lim
AU - L. Touyon
AU - L. Mak
AU - Y. C. Lau
AU - S. M. S. Cheng
AU - D. K. M. Ip
AU - M. Peiris
AU - B. J. Cowling
AU - S.-S. Wong
PY - 2026
DA - 2026/08/19
PB - medRxiv
DO - 10.64898/2026.08.19.26360857
UR - https://www.medrxiv.org/content/10.64898/2026.08.19.26360857v2
AB - We compared the immunogenicity of three licensed egg-based inactivated influenza vaccines, including TetrAnflu (Sinovac quadrivalent), Fluarix Tetra (GSK quadrivalent), and Vaxigrip (Sanofi trivalent), in adult healthcare workers in Hong Kong during the 2025/26 season. Age- and sex-matched recipients (n=30-40 per group) with paired pre- and post-vaccination sera were identified from an ongoing cohort. Hemagglutination-inhibition assays were performed against the egg-propagated 2025/26 vaccine reference strains. The three vaccines induced broadly comparable geometric mean fold-rises, post-vaccination geometric mean titers, proportions achieving titers >=40, and seroconversion rates against vaccine strains. These real-world data support the interchangeability of the three products for seasonal influenza vaccination programs among healthcare workers.
ER -