A noncanonical meiotic cohesin complex associates with specific MCM complexes to promote cohesion establishment and homolog bias
- 1School of Life and Health Sciences, Hainan University, Haikou, China.
- 2School of Tropical Agriculture and Forestry, Hainan University, Haikou, China.
- 3National Nanfan Research Institute, Chinese Academy of Agricultural Sciences, Sanya, China.
Abstract
A meiosis-specific cohesin complex is essential for the segregation of homologous chromosomes and sister chromatids during meiosis, yet its composition and mechanism in Drosophila remain elusive. Here, we demonstrate that SOLO directly interacts with SUNN, SSEP, and SMC1 and that these interactions are conserved between Drosophila melanogaster and Zeugodacus cucurbitae, a Tephritidae species within Diptera. SOLO associates with SMC1 via specific conserved residues within its highly conserved carboxyl-terminal domain. Furthermore, SOLO directly interacts with the MCM4 and MCM6 subunits of the MCM complex and with MMS22L to establish cohesion; consequently, postreplicative expression of SOLO results in a complete function loss. SOLO also interacts with the MEI-217 and MEI-218 subunits of the meiosis-specific minichromosome maintenance complex to promote homolog bias during meiosis. We propose that in Diptera, an evolutionarily diverged meiotic cohesin complex, composed of SOLO, SUNN, SSEP, SMC1, and SMC3, interacts with various complexes to fulfill its diverse meiotic functions.
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BibTeX
@article{ma2026noncanonical,
title = {{A noncanonical meiotic cohesin complex associates with specific MCM complexes to promote cohesion establishment and homolog bias}},
author = {Lujie Ma and Qianqian Jin and Dongcheng Hu and Xianwu Lin and Zizhen Fan and Rihui Yan},
journal = {Science Advances},
year = {2026},
month = oct,
doi = {10.1126/sciadv.aej1008},
url = {https://www.science.org/doi/10.1126/sciadv.aej1008},
note = {CC BY},
}
RIS
TY - JOUR
TI - A noncanonical meiotic cohesin complex associates with specific MCM complexes to promote cohesion establishment and homolog bias
AU - Lujie Ma
AU - Qianqian Jin
AU - Dongcheng Hu
AU - Xianwu Lin
AU - Zizhen Fan
AU - Rihui Yan
PY - 2026
DA - 2026/10/23
JO - Science Advances
DO - 10.1126/sciadv.aej1008
UR - https://www.science.org/doi/10.1126/sciadv.aej1008
AB - A meiosis-specific cohesin complex is essential for the segregation of homologous chromosomes and sister chromatids during meiosis, yet its composition and mechanism in Drosophila remain elusive. Here, we demonstrate that SOLO directly interacts with SUNN, SSEP, and SMC1 and that these interactions are conserved between Drosophila melanogaster and Zeugodacus cucurbitae, a Tephritidae species within Diptera. SOLO associates with SMC1 via specific conserved residues within its highly conserved carboxyl-terminal domain. Furthermore, SOLO directly interacts with the MCM4 and MCM6 subunits of the MCM complex and with MMS22L to establish cohesion; consequently, postreplicative expression of SOLO results in a complete function loss. SOLO also interacts with the MEI-217 and MEI-218 subunits of the meiosis-specific minichromosome maintenance complex to promote homolog bias during meiosis. We propose that in Diptera, an evolutionarily diverged meiotic cohesin complex, composed of SOLO, SUNN, SSEP, SMC1, and SMC3, interacts with various complexes to fulfill its diverse meiotic functions.
SN - 2375-2548
ER -