The number of painful procedures undergone by premature neonates amplifies their repetition suppression and deviance detection of innocuous stimuli in a tactile oddball protocol
Abstract
Sensory prediction (SP) is a fundamental mechanism of perception that supports cognitive development. Atypical SP has been reported across multiple neurodevelopmental disorders (ND), suggesting it may constitute an early cross-syndromic marker. Premature birth is a major risk factor for ND, with risk increasing as gestational age (GA) at birth decreases. However, how perinatal risk factors shape the development of SP remains poorly understood. We do not know if untimely birth itself, or exposure to iatrogenic pain during neonatal intensive care, cause neurodevelopmental impairments. In this study, we first assessed whether SP can be detected in the brains of premature neonates at 35 weeks corrected GA using a tactile oddballomission paradigm with EEG. We then examined the effects of the degree of prematurity and of the exposure to painful care procedures on neural indices of SP. Results demonstrate the presence of repetition suppression (RS) and a mismatch response (MMR) to deviant stimuli in the contralateral somatosensory cortex of premature neonates. The amplitude of these SP proxies was significantly affected by the number of painful procedures experienced since birth, independently of the effect of GA at birth. Contrary to our initial hypothesis that greater neurodevelopmental risk would be associated with less mature SP, infants with higher exposure to pain exhibited more robust indices of SP. These findings suggest that increased ex utero experience, even painful, is associated with accelerated maturation of predictive somatosensory processing. Longitudinal follow-up of participants at age 2 will explore how these early markers relate to developmental outcomes.
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BibTeX
@misc{marais2026number,
title = {{The number of painful procedures undergone by premature neonates amplifies their repetition suppression and deviance detection of innocuous stimuli in a tactile oddball protocol}},
author = {Anne-Lise Marais and Victoria Dumont and Marie Anquetil and Arnaud Mortier and Anne-Sophie Trentesaux and Nadege Roche-Labarbe},
howpublished = {HAL},
year = {2026},
month = sep,
eprint = {2512.23301},
archivePrefix = {arXiv},
url = {https://hal.science/hal-05424013v2},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - UNPB
TI - The number of painful procedures undergone by premature neonates amplifies their repetition suppression and deviance detection of innocuous stimuli in a tactile oddball protocol
AU - Anne-Lise Marais
AU - Victoria Dumont
AU - Marie Anquetil
AU - Arnaud Mortier
AU - Anne-Sophie Trentesaux
AU - Nadege Roche-Labarbe
PY - 2026
DA - 2026/09/11
PB - HAL
UR - https://hal.science/hal-05424013v2
AB - Sensory prediction (SP) is a fundamental mechanism of perception that supports cognitive development. Atypical SP has been reported across multiple neurodevelopmental disorders (ND), suggesting it may constitute an early cross-syndromic marker. Premature birth is a major risk factor for ND, with risk increasing as gestational age (GA) at birth decreases. However, how perinatal risk factors shape the development of SP remains poorly understood. We do not know if untimely birth itself, or exposure to iatrogenic pain during neonatal intensive care, cause neurodevelopmental impairments. In this study, we first assessed whether SP can be detected in the brains of premature neonates at 35 weeks corrected GA using a tactile oddballomission paradigm with EEG. We then examined the effects of the degree of prematurity and of the exposure to painful care procedures on neural indices of SP. Results demonstrate the presence of repetition suppression (RS) and a mismatch response (MMR) to deviant stimuli in the contralateral somatosensory cortex of premature neonates. The amplitude of these SP proxies was significantly affected by the number of painful procedures experienced since birth, independently of the effect of GA at birth. Contrary to our initial hypothesis that greater neurodevelopmental risk would be associated with less mature SP, infants with higher exposure to pain exhibited more robust indices of SP. These findings suggest that increased ex utero experience, even painful, is associated with accelerated maturation of predictive somatosensory processing. Longitudinal follow-up of participants at age 2 will explore how these early markers relate to developmental outcomes.
ER -