A bibliometric analysis of global research trends in tumor microenvironment based nanotherapy.
4 affiliations
- 1Department of Oncology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
- 2Department of Oncology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China. [email protected].
- 3Department of Information, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
- 4Department of Oncology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China. [email protected].
Abstract
Background
The tumor microenvironment (TME) is a key factor in cancer progression and drug resistance. Nanomedicine provides a new solution to overcome the limitations of traditional therapies by regulating the TME. With the rapid growth of interdisciplinary research in this field, although there are many descriptive reviews, there is still a lack of a quantitative analysis of long-term research results.Methods
Literature from the Web of Science database was analyzed to reveal the knowledge structure, the evolution of core concepts, and the future research frontier in this field using VOSviewer, CiteSpace, R-bibliometrix, and R packages.Results
Analysis shows that the number of relevant publications has grown rapidly since 2020, and China and the Chinese Academy of Sciences have made outstanding contributions. The dynamic evolution of Subject Categories and Research Themes clarifies the development trajectory of this field from the basic drug delivery theme to the regulation of the complex TME. Keyword co-occurrence analysis identifies core knowledge areas such as ROS-based therapies, metabolic control, immune microenvironment remodeling, and drug delivery. The analysis of cited references and highly cited literature reveals the knowledge base and milestone research that drive the development of this field. The current research frontier and hot spots focus on reshaping the immune microenvironment, novel regulated cell death mechanisms, ROS-based therapies, tumor metabolic reprogramming, combination therapies, and biomimetic/theranostic platforms.Conclusions
This study reveals the paradigm shift in nanomaterials from passive delivery carriers to multifunctional, bioactive regulators of the TME. Through quantitative analysis, the future development direction of multi-target synergistic intervention is clarified, which provides an important reference for the follow-up research on personalized tumor treatment.
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BibTeX
@article{wu2026bibliometric,
title = {{A bibliometric analysis of global research trends in tumor microenvironment based nanotherapy.}},
author = {Beibei Wu and Rui Li and Yufei Yang and Mengmeng Wang and Jian Liu and Liang Guan and Jiaxi Liu and Chunhui Ning and Yuying Xu},
journal = {Discover nano},
year = {2026},
month = oct,
doi = {10.1186/s11671-026-04990-z},
url = {https://europepmc.org/article/MED/42909804},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - A bibliometric analysis of global research trends in tumor microenvironment based nanotherapy.
AU - Beibei Wu
AU - Rui Li
AU - Yufei Yang
AU - Mengmeng Wang
AU - Jian Liu
AU - Liang Guan
AU - Jiaxi Liu
AU - Chunhui Ning
AU - Yuying Xu
PY - 2026
DA - 2026/10/23
JO - Discover nano
DO - 10.1186/s11671-026-04990-z
UR - https://europepmc.org/article/MED/42909804
AB - Background The tumor microenvironment (TME) is a key factor in cancer progression and drug resistance. Nanomedicine provides a new solution to overcome the limitations of traditional therapies by regulating the TME. With the rapid growth of interdisciplinary research in this field, although there are many descriptive reviews, there is still a lack of a quantitative analysis of long-term research results.Methods Literature from the Web of Science database was analyzed to reveal the knowledge structure, the evolution of core concepts, and the future research frontier in this field using VOSviewer, CiteSpace, R-bibliometrix, and R packages.Results Analysis shows that the number of relevant publications has grown rapidly since 2020, and China and the Chinese Academy of Sciences have made outstanding contributions. The dynamic evolution of Subject Categories and Research Themes clarifies the development trajectory of this field from the basic drug delivery theme to the regulation of the complex TME. Keyword co-occurrence analysis identifies core knowledge areas such as ROS-based therapies, metabolic control, immune microenvironment remodeling, and drug delivery. The analysis of cited references and highly cited literature reveals the knowledge base and milestone research that drive the development of this field. The current research frontier and hot spots focus on reshaping the immune microenvironment, novel regulated cell death mechanisms, ROS-based therapies, tumor metabolic reprogramming, combination therapies, and biomimetic/theranostic platforms.Conclusions This study reveals the paradigm shift in nanomaterials from passive delivery carriers to multifunctional, bioactive regulators of the TME. Through quantitative analysis, the future development direction of multi-target synergistic intervention is clarified, which provides an important reference for the follow-up research on personalized tumor treatment.
SN - 2731-9229
ER -