Iron-Catalyzed Nitrene Transfer Reactions Enabled by Hydroxylamine Derivatives.
Abstract
The synthesis of nitrogen-containing compounds and heterocycles is of central importance in organic chemistry, as many biologically active molecules contain at least one C-N bond. Among the various strategies available for C-N bond formation, transition-metal-catalyzed nitrene transfer has emerged as a versatile approach. Although numerous nitrene precursors and catalytic systems have been developed over the years, increasing attention has recently been devoted to more sustainable methodologies. In this context, we have developed a range of iron-catalyzed nitrene transfer reactions employing hydroxylamine-derived reagents as nitrene precursors, thereby providing attractive and sustainable alternatives to conventional systems based on noble-metal catalysts and iminoiodinane or azide reagents.
Related
- Chemical Non-Innocence in Mn Porphyrin-Catalyzed Nitrene Transfer
- Synthesis of 5-[3-amino-imidazo[1,2- a ]pyridin-6-yl]pyridin-2-ones and derivatives through the combination of palladium-catalyzed cross-coupling and GBB multi-component reactions
- Nitrene-Transfer Chemistry to Olefins Mediated by Co(III) Catalysts Supported by a Tetraamido Macrocycle.
- Base-catalyzed intramolecular C–H annulation reactions of o-carboranes containing nitriles, alkynes, and alkenes
- Oxidative functionalization of aliphatic and aromatic amino acid derivatives with H 2 O 2 catalyzed by a nonheme imine based iron complex
BibTeX
@article{berhal2026ironcatalyzed,
title = {{Iron-Catalyzed Nitrene Transfer Reactions Enabled by Hydroxylamine Derivatives.}},
author = {Farouk Berhal and Guillaume Prestat},
journal = {SYNLETT},
year = {2026},
month = sep,
doi = {10.1055/a-2956-2695},
url = {https://u-paris.hal.science/hal-05763021v1},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Iron-Catalyzed Nitrene Transfer Reactions Enabled by Hydroxylamine Derivatives.
AU - Farouk Berhal
AU - Guillaume Prestat
PY - 2026
DA - 2026/09/09
JO - SYNLETT
DO - 10.1055/a-2956-2695
UR - https://u-paris.hal.science/hal-05763021v1
AB - The synthesis of nitrogen-containing compounds and heterocycles is of central importance in organic chemistry, as many biologically active molecules contain at least one C-N bond. Among the various strategies available for C-N bond formation, transition-metal-catalyzed nitrene transfer has emerged as a versatile approach. Although numerous nitrene precursors and catalytic systems have been developed over the years, increasing attention has recently been devoted to more sustainable methodologies. In this context, we have developed a range of iron-catalyzed nitrene transfer reactions employing hydroxylamine-derived reagents as nitrene precursors, thereby providing attractive and sustainable alternatives to conventional systems based on noble-metal catalysts and iminoiodinane or azide reagents.
SN - 0936-5214
SN - 1437-2096
ER -