Convergent Mitochondrial and Oxidative Stress Signatures in Spaceflight and Tauopathy: A Comparative Multi-Omics Reanalysis in Drosophila melanogaster
- 1Florida International University
Abstract
Mitochondrial dysfunction is a shared biological thread between terrestrial Alzheimer's disease (AD) and in the unique stress environment of spaceflight, making mitochondrial pathophysiology a compelling target for comparative investigation. In AD, mitochondrial impairment is closely linked to defective oxidative phosphorylation, reactive oxygen species accumulation, calcium dysregulation, and neuronal injury, while spaceflight stressors such as microgravity and radiation disrupt mitochondrial homeostasis and increase oxidative stress. Understanding how the extreme stressors of spacelight affect mitochondrial function may provide insights into conserved mitochondrial stress responses and their implications for neurodegenerative diseases, including AD. Our study compares datasets from ground control Drosophila melanogaster RNA-seq with isolated radiation and microgravity exposure to discern conserved mitochondrial pathways and molecular signatures that may provide insights into AD mechanisms.
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BibTeX
@misc{navarro2026convergent,
title = {{Convergent Mitochondrial and Oxidative Stress Signatures in Spaceflight and Tauopathy: A Comparative Multi-Omics Reanalysis in Drosophila melanogaster}},
author = {M. Navarro and J. Aquino and K. Shi and H. Lin and V. Monfared and J. C. Garcia and A. Seylani and M. Komedera and J. Moutinho and J. Romils and A. Venosa and A. Kelam and V. C. Bortolotto and J. Chen and M. Gebre and M. W. McNerney},
howpublished = {bioRxiv},
year = {2026},
month = oct,
doi = {10.64898/2026.10.16.759726},
url = {https://www.biorxiv.org/content/10.64898/2026.10.16.759726v1},
note = {CC BY},
}
RIS
TY - UNPB
TI - Convergent Mitochondrial and Oxidative Stress Signatures in Spaceflight and Tauopathy: A Comparative Multi-Omics Reanalysis in Drosophila melanogaster
AU - M. Navarro
AU - J. Aquino
AU - K. Shi
AU - H. Lin
AU - V. Monfared
AU - J. C. Garcia
AU - A. Seylani
AU - M. Komedera
AU - J. Moutinho
AU - J. Romils
AU - A. Venosa
AU - A. Kelam
AU - V. C. Bortolotto
AU - J. Chen
AU - M. Gebre
AU - M. W. McNerney
PY - 2026
DA - 2026/10/16
PB - bioRxiv
DO - 10.64898/2026.10.16.759726
UR - https://www.biorxiv.org/content/10.64898/2026.10.16.759726v1
AB - Mitochondrial dysfunction is a shared biological thread between terrestrial Alzheimer's disease (AD) and in the unique stress environment of spaceflight, making mitochondrial pathophysiology a compelling target for comparative investigation. In AD, mitochondrial impairment is closely linked to defective oxidative phosphorylation, reactive oxygen species accumulation, calcium dysregulation, and neuronal injury, while spaceflight stressors such as microgravity and radiation disrupt mitochondrial homeostasis and increase oxidative stress. Understanding how the extreme stressors of spacelight affect mitochondrial function may provide insights into conserved mitochondrial stress responses and their implications for neurodegenerative diseases, including AD. Our study compares datasets from ground control Drosophila melanogaster RNA-seq with isolated radiation and microgravity exposure to discern conserved mitochondrial pathways and molecular signatures that may provide insights into AD mechanisms.
ER -