Development and Evaluation of a Dietary Polysaccharide-Stabilized Peptide-Fe²⁺ Complex Beverage for Iron Deficiency Anemia Intervention.
5 affiliations
- 1College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
- 2Key Laboratory of Aquatic Product Processing, Ministry of Agriculture and Rural Affairs, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510300, China.
- 3State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao 266400, China.
- 4Institute of Agro-Products Processing Science and Technology, Guangxi Academy of Agricultural Sciences, Nanning 530007, China.
- 5Sanya Tropical Fisheries Research Institute, Sanya 572000, China.
Abstract
This study developed a dietary polysaccharide-stabilized peptide-Fe²⁺ composite beverage to address iron deficiency anemia (IDA). Through single-factor and orthogonal experiments, the formulation was optimized (cranberry/blueberry concentrate ratio 4:6, 600 mL/L; FA-COS@Peptide-Fe²⁺@PTry-CMC 200 mL/L; vitamin C 1.5 g/L; pectin 0.06 g/L), and processing parameters were determined (homogenization: 12,000 rpm, 20 min; sterilization: 95 °C, 15 min). Storage stability was optimal at 4 °C in dark conditions. Under the optimal processing conditions, the beverage attained a maximum suspension stability of 17.74% and the optimized formulation achieved a highest sensory score of 94.0 (out of 100). In vivo experiments showed that the beverage dose-dependently restored hematological parameters (e.g., HGB, SI, TIBC) and tissue iron levels, alleviated intestinal oxidative stress and inflammatory markers in IDA mice, while repairing colonic mucosal damage without adverse effects. The beverage demonstrated high iron-supplementing efficacy and excellent biosafety, offering a promising strategy for IDA intervention.
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BibTeX
@article{liang2026development,
title = {{Development and Evaluation of a Dietary Polysaccharide-Stabilized Peptide-Fe²⁺ Complex Beverage for Iron Deficiency Anemia Intervention.}},
author = {Yongqian Liang and Shanting Lin and Shengjun Chen and Yongqiang Zhao and Hui Huang and Zhenxing Li and Xiao Hu},
journal = {Foods (Basel, Switzerland)},
year = {2026},
month = oct,
doi = {10.3390/foods15203644},
url = {https://europepmc.org/article/MED/42940281},
note = {CC BY},
}
RIS
TY - JOUR
TI - Development and Evaluation of a Dietary Polysaccharide-Stabilized Peptide-Fe²⁺ Complex Beverage for Iron Deficiency Anemia Intervention.
AU - Yongqian Liang
AU - Shanting Lin
AU - Shengjun Chen
AU - Yongqiang Zhao
AU - Hui Huang
AU - Zhenxing Li
AU - Xiao Hu
PY - 2026
DA - 2026/10/14
JO - Foods (Basel, Switzerland)
DO - 10.3390/foods15203644
UR - https://europepmc.org/article/MED/42940281
AB - This study developed a dietary polysaccharide-stabilized peptide-Fe²⁺ composite beverage to address iron deficiency anemia (IDA). Through single-factor and orthogonal experiments, the formulation was optimized (cranberry/blueberry concentrate ratio 4:6, 600 mL/L; FA-COS@Peptide-Fe²⁺@PTry-CMC 200 mL/L; vitamin C 1.5 g/L; pectin 0.06 g/L), and processing parameters were determined (homogenization: 12,000 rpm, 20 min; sterilization: 95 °C, 15 min). Storage stability was optimal at 4 °C in dark conditions. Under the optimal processing conditions, the beverage attained a maximum suspension stability of 17.74% and the optimized formulation achieved a highest sensory score of 94.0 (out of 100). In vivo experiments showed that the beverage dose-dependently restored hematological parameters (e.g., HGB, SI, TIBC) and tissue iron levels, alleviated intestinal oxidative stress and inflammatory markers in IDA mice, while repairing colonic mucosal damage without adverse effects. The beverage demonstrated high iron-supplementing efficacy and excellent biosafety, offering a promising strategy for IDA intervention.
SN - 2304-8158
ER -