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Peer-reviewedCC BY 4.0Transboundary and Emerging Diseases

Genomic Recombination and Genetic Diversity of Emerging Novel Duck Orthoreovirus in China, 2018–2023

  • Chenchen Jiang1
  • Rongchang Liu2
  • Bing Li3
  • Wenzhe Liu1
  • Di Lei1
  • Yu Huang2
  • Chunhe Wan2
  • Yi Tang3
  • Rendong Fang1
  • Hongzhi Wang1
  1. 1College of Veterinary Medicine Southwest University Beibei Chongqing China swu.edu.cn
  2. 2Fujian Provincial Key Laboratory for Avian Diseases Control and Prevention Institute of Animal Husbandry and Veterinary Medicine of Fujian Academy of Agricultural Sciences Fuzhou Fujian China
  3. 3Institute of Animal Sciences of Chinese Academy of Agricultural Sciences Haidian Beijing China caas.cn
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Abstract

Novel duck orthoreovirus (NDRV) represents a major pathogen severely affecting the waterfowl farming industry in China, yet its evolutionary dynamics and reassortment patterns remain poorly defined. In this study, we sequenced the full genomes of 10 NDRV isolates obtained from Shandong and Jiangsu provinces (2018–2023) and analyzed their genetic features through sequence identity, phylogenetics, and reassortment detection. We also evaluated pathogenicity in 1‐day‐old ducklings for three representative isolates via intravenous injection. Our results show that nucleotide (nt) homologies across all gene segments ranged from 86.9% to 99.9%, and the L2, M1, S2, and S4 segments displayed greater sequence variability than the traditionally hypervariable S1 gene in our isolates. We identified recombination events in the M2 segment of strain XT18 (with SDYC and HN5d as parental strains) and the S4 segment of strain LY20 (with GX‐Y7 and SDYC as parents), which, to our knowledge, represent the first reports of recombination in the M2 and S4 segments of NDRV. In pathogenicity tests, strain SDYC induced the most severe splenic lesions and maintained the highest viral loads in vivo. Collectively, these findings clarify the molecular evolution and reassortment landscape of currently circulating NDRV strains and offer a scientific basis for selecting vaccine candidates and designing precision control strategies.

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Cite

BibTeXRIS
BibTeX
@article{jiang2026genomic,
  title = {{Genomic Recombination and Genetic Diversity of Emerging Novel Duck Orthoreovirus in China, 2018–2023}},
  author = {Chenchen Jiang and Rongchang Liu and Bing Li and Wenzhe Liu and Di Lei and Yu Huang and Chunhe Wan and Yi Tang and Rendong Fang and Hongzhi Wang},
  journal = {Transboundary and Emerging Diseases},
  year = {2026},
  month = nov,
  doi = {10.1155/tbed/7746288},
  url = {https://doi.org/10.1155/tbed/7746288},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Genomic Recombination and Genetic Diversity of Emerging Novel Duck Orthoreovirus in China, 2018–2023
AU  - Chenchen Jiang
AU  - Rongchang Liu
AU  - Bing Li
AU  - Wenzhe Liu
AU  - Di Lei
AU  - Yu Huang
AU  - Chunhe Wan
AU  - Yi Tang
AU  - Rendong Fang
AU  - Hongzhi Wang
PY  - 2026
DA  - 2026/11/05
JO  - Transboundary and Emerging Diseases
DO  - 10.1155/tbed/7746288
UR  - https://doi.org/10.1155/tbed/7746288
AB  - Novel duck orthoreovirus (NDRV) represents a major pathogen severely affecting the waterfowl farming industry in China, yet its evolutionary dynamics and reassortment patterns remain poorly defined. In this study, we sequenced the full genomes of 10 NDRV isolates obtained from Shandong and Jiangsu provinces (2018–2023) and analyzed their genetic features through sequence identity, phylogenetics, and reassortment detection. We also evaluated pathogenicity in 1‐day‐old ducklings for three representative isolates via intravenous injection. Our results show that nucleotide (nt) homologies across all gene segments ranged from 86.9% to 99.9%, and the L2, M1, S2, and S4 segments displayed greater sequence variability than the traditionally hypervariable S1 gene in our isolates. We identified recombination events in the M2 segment of strain XT18 (with SDYC and HN5d as parental strains) and the S4 segment of strain LY20 (with GX‐Y7 and SDYC as parents), which, to our knowledge, represent the first reports of recombination in the M2 and S4 segments of NDRV. In pathogenicity tests, strain SDYC induced the most severe splenic lesions and maintained the highest viral loads in vivo. Collectively, these findings clarify the molecular evolution and reassortment landscape of currently circulating NDRV strains and offer a scientific basis for selecting vaccine candidates and designing precision control strategies.
SN  - 1865-1674
SN  - 1865-1682
ER  -