Assessing the effect of subthalamic stimulation on metaperception in obsessive-compulsive disorder
Abstract
Most human studies on perceptual decision-making are correlational, and few addressed the causal role of the neural markers they identify. Here, we took the opportunity offered by deep brain stimulation to study the causal role of subthalamo-cortical networks on perceptual decision-making and perceptual monitoring. We asked participants with obsessive-compulsive disorder (OCD) treated with subthalamic stimulation to detect visual stimuli and provide confidence reports while we recorded scalp electroencephalography. Following a preregistered plan, we compared behavioural and neural results between patients off-stimulation and matched healthy controls and among patients on and off-stimulation to identify the effect of subthalamic stimulation on perceptual choices and metacognitive judgments. Our results indicate that patients off-stimulation detected visual stimuli similarly to matched healthy controls but provided poorer confidence judgments, indicative of a potential metacognitive alteration. Moreover, chronic subthalamic stimulation significantly reduced clinical symptoms, but acute stimulation changes did not impact visual detection, confidence, nor corresponding event-related potentials at the scalp level. We conclude that acute changes in subthalamic stimulation are insufficient to modify the potential metacognitive alterations observed in OCD.
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BibTeX
@article{kist2026assessing,
title = {{Assessing the effect of subthalamic stimulation on metaperception in obsessive-compulsive disorder}},
author = {Audrey Kist and Michael Pereira and Ramla Msheik and Dorian Goueytes and Arnaud Pouchon and Stephan Chabardès and Julien Bastin and Mircea Polosan and Nathan Faivre},
journal = {Translational Psychiatry},
year = {2026},
month = sep,
doi = {10.1038/s41398-026-04423-6},
url = {https://hal.science/hal-05737263v1},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Assessing the effect of subthalamic stimulation on metaperception in obsessive-compulsive disorder
AU - Audrey Kist
AU - Michael Pereira
AU - Ramla Msheik
AU - Dorian Goueytes
AU - Arnaud Pouchon
AU - Stephan Chabardès
AU - Julien Bastin
AU - Mircea Polosan
AU - Nathan Faivre
PY - 2026
DA - 2026/09/03
JO - Translational Psychiatry
DO - 10.1038/s41398-026-04423-6
UR - https://hal.science/hal-05737263v1
AB - Most human studies on perceptual decision-making are correlational, and few addressed the causal role of the neural markers they identify. Here, we took the opportunity offered by deep brain stimulation to study the causal role of subthalamo-cortical networks on perceptual decision-making and perceptual monitoring. We asked participants with obsessive-compulsive disorder (OCD) treated with subthalamic stimulation to detect visual stimuli and provide confidence reports while we recorded scalp electroencephalography. Following a preregistered plan, we compared behavioural and neural results between patients off-stimulation and matched healthy controls and among patients on and off-stimulation to identify the effect of subthalamic stimulation on perceptual choices and metacognitive judgments. Our results indicate that patients off-stimulation detected visual stimuli similarly to matched healthy controls but provided poorer confidence judgments, indicative of a potential metacognitive alteration. Moreover, chronic subthalamic stimulation significantly reduced clinical symptoms, but acute stimulation changes did not impact visual detection, confidence, nor corresponding event-related potentials at the scalp level. We conclude that acute changes in subthalamic stimulation are insufficient to modify the potential metacognitive alterations observed in OCD.
SN - 2158-3188
SN - 2158-3188
ER -