The role and therapeutic potential of cGAS-STING signaling in acute pancreatitis: from the perspectives of inflammation and cell death
- 1Emergency Department, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, Guangdong, China
Abstract
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway can recognize pathogen-derived and host DNA. This factor triggers innate immune responses and thereby establishes a broad and effective surveillance mechanism for tissue damage and pathogen invasion. In acute pancreatitis (AP), the cGAS-STING signaling pathway exerts diverse regulatory functions during the process of pancreatic cell death. We systematically review the molecular mechanism of the cGAS-STING signaling pathway in acute pancreatitis. We summarize the latest research progress on the interaction of this pathway with various forms of programmed cell death. Through specific case analyses, we elaborate on the key role of the cGAS-STING signaling pathway in regulating apoptosis, autophagy, ferroptosis, pyroptosis and inflammatory responses. Finally, this article also explores the potential research value of several natural plant-derived compounds. They achieve this by regulating this pathway and thereby interfering with the mechanism of cell death during the pathological process of acute pancreatitis.
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BibTeX
@article{wang2026role,
title = {{The role and therapeutic potential of cGAS-STING signaling in acute pancreatitis: from the perspectives of inflammation and cell death}},
author = {Hanli Wang and Lingling Wen and Haiyang Wang and Yuxiang Liu and Zhizhun Mo},
journal = {Frontiers in Physiology},
year = {2026},
month = oct,
doi = {10.3389/fphys.2026.1976652},
url = {https://doi.org/10.3389/fphys.2026.1976652},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - The role and therapeutic potential of cGAS-STING signaling in acute pancreatitis: from the perspectives of inflammation and cell death
AU - Hanli Wang
AU - Lingling Wen
AU - Haiyang Wang
AU - Yuxiang Liu
AU - Zhizhun Mo
PY - 2026
DA - 2026/10/26
JO - Frontiers in Physiology
DO - 10.3389/fphys.2026.1976652
UR - https://doi.org/10.3389/fphys.2026.1976652
AB - The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway can recognize pathogen-derived and host DNA. This factor triggers innate immune responses and thereby establishes a broad and effective surveillance mechanism for tissue damage and pathogen invasion. In acute pancreatitis (AP), the cGAS-STING signaling pathway exerts diverse regulatory functions during the process of pancreatic cell death. We systematically review the molecular mechanism of the cGAS-STING signaling pathway in acute pancreatitis. We summarize the latest research progress on the interaction of this pathway with various forms of programmed cell death. Through specific case analyses, we elaborate on the key role of the cGAS-STING signaling pathway in regulating apoptosis, autophagy, ferroptosis, pyroptosis and inflammatory responses. Finally, this article also explores the potential research value of several natural plant-derived compounds. They achieve this by regulating this pathway and thereby interfering with the mechanism of cell death during the pathological process of acute pancreatitis.
SN - 1664-042X
ER -