Reducing photosensitizer aggregation via cyclodextrin-adamantane porphyrin host-guest interactions for enhanced photodynamic therapy.
- 1School of Medicine, Anhui University of Science and Technology Huainan 232001 P. R. China.
- 2Institute of Hepatobiliary and Pancreatic Surgery, Department of Hepatobiliary and Pancreatic Surgery, Shanghai East Hospital, School of Medicine, Tongji University Shanghai 200120 P. R. China [email protected] [email protected].
Abstract
The production yield of singlet oxygen (¹O₂) directly determines the therapeutic efficacy of photodynamic therapy (PDT). However, photosensitizer aggregation seriously suppresses ¹O₂ production. Herein, we developed a host-guest complexation-based isolation strategy that prevents photosensitizers' aggregation, enhances ¹O₂ generation and ultimately boosts the photodynamic killing performance. Specifically, we synthesized ultra-small Cu2-x Se-CD nanoparticles as a supramolecular loading platform and loaded them with adamantane-functionalized 5-(4-hydroxyphenyl)-10,15,20-triphenylporphyrin (Ada-TPP) to obtain a supramolecular nano-photosensitizer Cu2-x Se-CD-TPP. In this construct each photosensitizer molecule is individually confined within the cavity of a cyclodextrin unit anchored on the surface of Cu2-x Se nanoparticles, endowing the material with excellent dispersibility and effectively suppressing the photosensitizer's aggregation. This rational structural design results in an 84.8% increase in ¹O₂ production yield. Both in vitro and in vivo experiments confirm that Cu2-x Se-CD-TPP achieves efficient tumor therapy under light irradiation. Collectively, this study not only provides a robust strategy to mitigate photosensitizers' aggregation, but also develops a promising nanomaterial for precise and high-efficacy photodynamic therapy.
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BibTeX
@article{liu2026reducing,
title = {{Reducing photosensitizer aggregation via cyclodextrin-adamantane porphyrin host-guest interactions for enhanced photodynamic therapy.}},
author = {Chengcheng Liu and Lijun Yue and Chuning Jia and Yelin Wu and Chaochao Wang},
journal = {RSC advances},
year = {2026},
month = oct,
doi = {10.1039/d6ra05237a},
url = {https://europepmc.org/article/MED/42948371},
note = {CC BY},
}
RIS
TY - JOUR
TI - Reducing photosensitizer aggregation via cyclodextrin-adamantane porphyrin host-guest interactions for enhanced photodynamic therapy.
AU - Chengcheng Liu
AU - Lijun Yue
AU - Chuning Jia
AU - Yelin Wu
AU - Chaochao Wang
PY - 2026
DA - 2026/10/27
JO - RSC advances
DO - 10.1039/d6ra05237a
UR - https://europepmc.org/article/MED/42948371
AB - The production yield of singlet oxygen (¹O₂) directly determines the therapeutic efficacy of photodynamic therapy (PDT). However, photosensitizer aggregation seriously suppresses ¹O₂ production. Herein, we developed a host-guest complexation-based isolation strategy that prevents photosensitizers' aggregation, enhances ¹O₂ generation and ultimately boosts the photodynamic killing performance. Specifically, we synthesized ultra-small Cu2-x Se-CD nanoparticles as a supramolecular loading platform and loaded them with adamantane-functionalized 5-(4-hydroxyphenyl)-10,15,20-triphenylporphyrin (Ada-TPP) to obtain a supramolecular nano-photosensitizer Cu2-x Se-CD-TPP. In this construct each photosensitizer molecule is individually confined within the cavity of a cyclodextrin unit anchored on the surface of Cu2-x Se nanoparticles, endowing the material with excellent dispersibility and effectively suppressing the photosensitizer's aggregation. This rational structural design results in an 84.8% increase in ¹O₂ production yield. Both in vitro and in vivo experiments confirm that Cu2-x Se-CD-TPP achieves efficient tumor therapy under light irradiation. Collectively, this study not only provides a robust strategy to mitigate photosensitizers' aggregation, but also develops a promising nanomaterial for precise and high-efficacy photodynamic therapy.
SN - 2046-2069
ER -