Continuous Non-Invasive Haemodynamic Monitoring During Primary Percutaneous Coronary Intervention
- 1Department of Cardiology and Interventional Angiology, Kashubian Center for Heart and Vascular Diseases, Pomeranian Hospitals, 84-200 Wejherowo, Poland
- 2Department of Cardiology, Medical University of Gdansk, 80-214 Gdansk, Poland
Abstract
Background/Objectives: Haemodynamic assessment during primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI) is mostly restricted to continuous monitoring of arterial blood pressure. The volume-clamp method provides continuous non-invasive arterial pressure monitoring without the need for vascular access, together with simultaneous estimation of stroke volume, cardiac output and other haemodynamic variables, but its feasibility during primary PCI has not been evaluated. Methods: In this prospective observational study, 33 patients with STEMI undergoing primary PCI were monitored continuously (Acumen IQ, HemoSphere) at seven pre-specified timepoints: baseline, guidewire crossing of the culprit lesion, stent implantation, end of procedure, and after 1, 6 and 24 h. Patients with cardiogenic shock, ongoing cardiopulmonary resuscitation or symptom onset more than 24 h before admission were excluded. Cardiac index (CI), stroke volume index (SVI), systemic vascular resistance index (SVRI), pulse rate, dP/dt, mean arterial pressure (MAP) and the Hypotension Prediction Index (HPI) were analysed using linear mixed models with Holm correction within families of related tests. Results: Patients were aged 65.4 ± 12.7 years and 25 (76%) were men. The culprit vessel was the left anterior descending artery in 15 patients (45%), and ST-segment resolution exceeding 50% was achieved in 25 patients (76%). The overall time effect was significant for six of seven variables, all except pulse rate. At guidewire crossing, dP/dt rose by 183.7 mmHg/s (95% CI 87–276) in 25 of 29 patients (86%; corrected p = 0.008), with a concurrent rise in CI (corrected p = 0.042) and no change in pulse rate or MAP. At 24 h, CI, SVI and dP/dt were indistinguishable from baseline, whereas MAP (−13.7 mmHg) and SVRI (−427 dyn·s·cm−5·m2) were lower. SVI and MAP were unrelated (r = +0.057; p = 0.431) across 227 measurements, while SVI and pulse rate were inversely coupled (r = −0.434) in 28 of 33 patients. Increasing age was associated with lower CI and MAP and higher HPI values, but not with the change in arterial dP/dt at guidewire crossing. Patients with TIMI 0 flow had higher SVRI by 510 dyn·s·cm−5·m2. Baseline pulse rate and its changes were different depending on the culprit vessel. Conclusions: Continuous non-invasive haemodynamic monitoring was feasible during primary PCI for STEMI. Given the small sample, the absence of a control group and the lack of validation against a reference method, the findings are exploratory and their clinical value remains to be established.
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BibTeX
@article{klatt2026continuous,
title = {{Continuous Non-Invasive Haemodynamic Monitoring During Primary Percutaneous Coronary Intervention}},
author = {Adrian Klatt and Piotr Kasprzyk and Rafał Gałąska and Radosław Targoński and Marek Szołkiewicz and Łukasz Lewicki},
journal = {Journal of Clinical Medicine},
year = {2026},
month = oct,
doi = {10.3390/jcm15218307},
url = {https://www.mdpi.com/2077-0383/15/21/8307},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Continuous Non-Invasive Haemodynamic Monitoring During Primary Percutaneous Coronary Intervention
AU - Adrian Klatt
AU - Piotr Kasprzyk
AU - Rafał Gałąska
AU - Radosław Targoński
AU - Marek Szołkiewicz
AU - Łukasz Lewicki
PY - 2026
DA - 2026/10/25
JO - Journal of Clinical Medicine
DO - 10.3390/jcm15218307
UR - https://www.mdpi.com/2077-0383/15/21/8307
AB - Background/Objectives: Haemodynamic assessment during primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI) is mostly restricted to continuous monitoring of arterial blood pressure. The volume-clamp method provides continuous non-invasive arterial pressure monitoring without the need for vascular access, together with simultaneous estimation of stroke volume, cardiac output and other haemodynamic variables, but its feasibility during primary PCI has not been evaluated. Methods: In this prospective observational study, 33 patients with STEMI undergoing primary PCI were monitored continuously (Acumen IQ, HemoSphere) at seven pre-specified timepoints: baseline, guidewire crossing of the culprit lesion, stent implantation, end of procedure, and after 1, 6 and 24 h. Patients with cardiogenic shock, ongoing cardiopulmonary resuscitation or symptom onset more than 24 h before admission were excluded. Cardiac index (CI), stroke volume index (SVI), systemic vascular resistance index (SVRI), pulse rate, dP/dt, mean arterial pressure (MAP) and the Hypotension Prediction Index (HPI) were analysed using linear mixed models with Holm correction within families of related tests. Results: Patients were aged 65.4 ± 12.7 years and 25 (76%) were men. The culprit vessel was the left anterior descending artery in 15 patients (45%), and ST-segment resolution exceeding 50% was achieved in 25 patients (76%). The overall time effect was significant for six of seven variables, all except pulse rate. At guidewire crossing, dP/dt rose by 183.7 mmHg/s (95% CI 87–276) in 25 of 29 patients (86%; corrected p = 0.008), with a concurrent rise in CI (corrected p = 0.042) and no change in pulse rate or MAP. At 24 h, CI, SVI and dP/dt were indistinguishable from baseline, whereas MAP (−13.7 mmHg) and SVRI (−427 dyn·s·cm−5·m2) were lower. SVI and MAP were unrelated (r = +0.057; p = 0.431) across 227 measurements, while SVI and pulse rate were inversely coupled (r = −0.434) in 28 of 33 patients. Increasing age was associated with lower CI and MAP and higher HPI values, but not with the change in arterial dP/dt at guidewire crossing. Patients with TIMI 0 flow had higher SVRI by 510 dyn·s·cm−5·m2. Baseline pulse rate and its changes were different depending on the culprit vessel. Conclusions: Continuous non-invasive haemodynamic monitoring was feasible during primary PCI for STEMI. Given the small sample, the absence of a control group and the lack of validation against a reference method, the findings are exploratory and their clinical value remains to be established.
SN - 2077-0383
ER -