Peer-reviewedCC BY 4.0Frontiers in Oncology
Standardizing ototoxicity monitoring for children treated with cisplatin: an urgent call to action
23 affiliations
- 1Pediatric Audiology, Department of Pediatrics, Doernbecher Children’s Hospital, Oregon Health & Science University
- 2The Royal National ENT and Eastman Dental Hospitals, UCLH NHS Foundation Trust
- 3Pediatric Hematology and Oncology, Department of Pediatric and Adolescent Medicine, University of Lübeck
- 4Princess Máxima Center for Pediatric Oncology
- 5Department of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medicine, Cipto Mangunkusumo Hospital, University of Indonesia
- 6Pediatric Oncology/Hematology, Department of Pediatrics, Faculty of Medicine, Cipto Mangunkusumo General Hospital, University of Indonesia
- 7Department of Medical Biology, Faculty of Medicine, Universitas Indonesia
- 8Fairfax Audiology Sonus
- 9Pediatric Oncology/Hematology, Faculty of Medicine, Dr. Soetomo General Academic Hospital, Universitas Airlangga
- 10Department of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Utrecht
- 11UMC Utrecht Brain Center
- 12Veterans Affairs Portland Healthcare System, National Center for Rehabilitative Auditory Research
- 13Department of Otolaryngology, Head and Neck Surgery, Oregon Health & Science University
- 14Division of Environmental Toxicology, Department of Pharmacology, Faculty of Medicine, Andalas University
- 15Department of Otorhinolaryngology & Head and Neck Surgery, Istanbul Medeniyet University
- 16Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Dr. Soetomo General Academic Hospital, Universitas Airlangga
- 17Department of Otolaryngology, Faculty of Medicine, Lokman Hekim University
- 18Oncological-Hematological Day Hospital, Dr. von Hauner Children’s Hospital
- 19Faculty of Medicine, University of Münster, Münster, Germany; Faculty of Medicine, Universitas Indonesia
- 20Success Life After Cure Ltd
- 21Section of Phoniatrics and Pedaudiology, Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center
- 22Great Ormond Street Hospital for Children NHS Foundation Trust
- 23Department of Phoniatrics and Pedaudiology, University Hospital, University of Münster
Abstract
Over the past 25 years, considerable progress has been made in identifying the prevalence, risk factors, functional impacts, and protective strategies for cisplatin-induced ototoxicity. Despite these advances, ototoxicity monitoring and audiologic management of children undergoing cisplatin treatment remains inconsistent across clinical settings. This position paper from the German-Indonesian Society for Medicine (DIGM) Ototoxicity Working Group reflects a consensus process based on expert opinion, supported by a narrative review of the scientific literature and recently published recommendations regarding audiologic management of children receiving cisplatin chemotherapy. We advocate that ototoxicity monitoring be recognized as standard of care for every child receiving cisplatin and incorporated into pediatric cancer treatment protocols. This paper proposes a minimum benchmark for the audiologic management of children undergoing cisplatin chemotherapy; a standard that can be readily implemented in most clinical settings worldwide.
Related
- Cisplatin-Induced Ototoxicity in Head and Neck Cancer: A Systematic Review of Current Evidence, Clinical Implications, and the Need for Standardized Monitoring.
- Age‐Dependent Patterns of Cisplatin‐Induced Ototoxicity in Head and Neck Cancer: A Longitudinal Audiologic Analysis
- Avoiding Cisplatin-Related Hearing Loss, Including Implementing Sodium Thiosulfate as Otoprotectant Into Daily Pediatric Clinical Practice: Proceedings Based on Evidence and Expert Opinion From the Ototoxicity Taskforce of the SIOP Supportive Care Network
- Person‐Reported and Continuous Glucose Monitoring ( CGM ) Recorded Hypoglycaemia in People With Insulin‐Treated Type 2 Diabetes and Mild to Moderate Chronic Kidney Disease; Post Hoc Analysis From the Hypo‐ METRICS Study
- Comparison of nasal symmetry in children with unilateral oral clefts treated with/without nasoalveolar molding - a retrospective study with a mean age of 5 years
BibTeX
@article{knight2026standardizing,
title = {{Standardizing ototoxicity monitoring for children treated with cisplatin: an urgent call to action}},
author = {Kristin Knight and Milanka Drenovak and Thorsten Langer and Nienke Streefkerk and Tri Juda Airlangga and Murti Andriastuti and Asmarinah and Deborah Berndtson and Adwina Nurlita Kusuma Wardhani Hartantyo and Alexander E. Hoetink and Kim E. de Jager and Dawn Konrad Martin and Cimi Ilmiawati and M. Tayyar Kalcioglu and Ika Dewi Mayangsari and Nyilo Purnami and Shally Adhina Putri and Haldun Oguz and Irene Schmid and Rasjid Soeparwata and Helen Spoudeas and Anna-Katharina Rohlfs and Kaukab Rajput and Penelope Brock and Marry M. van den Heuvel-Eibrink and Antoinette am Zehnhoff-Dinnesen},
journal = {Frontiers in Oncology},
year = {2026},
month = oct,
doi = {10.3389/fonc.2026.1923166},
url = {https://www.frontiersin.org/articles/10.3389/fonc.2026.1923166/full},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Standardizing ototoxicity monitoring for children treated with cisplatin: an urgent call to action
AU - Kristin Knight
AU - Milanka Drenovak
AU - Thorsten Langer
AU - Nienke Streefkerk
AU - Tri Juda Airlangga
AU - Murti Andriastuti
AU - Asmarinah
AU - Deborah Berndtson
AU - Adwina Nurlita Kusuma Wardhani Hartantyo
AU - Alexander E. Hoetink
AU - Kim E. de Jager
AU - Dawn Konrad Martin
AU - Cimi Ilmiawati
AU - M. Tayyar Kalcioglu
AU - Ika Dewi Mayangsari
AU - Nyilo Purnami
AU - Shally Adhina Putri
AU - Haldun Oguz
AU - Irene Schmid
AU - Rasjid Soeparwata
AU - Helen Spoudeas
AU - Anna-Katharina Rohlfs
AU - Kaukab Rajput
AU - Penelope Brock
AU - Marry M. van den Heuvel-Eibrink
AU - Antoinette am Zehnhoff-Dinnesen
PY - 2026
DA - 2026/10/27
JO - Frontiers in Oncology
DO - 10.3389/fonc.2026.1923166
UR - https://www.frontiersin.org/articles/10.3389/fonc.2026.1923166/full
AB - Over the past 25 years, considerable progress has been made in identifying the prevalence, risk factors, functional impacts, and protective strategies for cisplatin-induced ototoxicity. Despite these advances, ototoxicity monitoring and audiologic management of children undergoing cisplatin treatment remains inconsistent across clinical settings. This position paper from the German-Indonesian Society for Medicine (DIGM) Ototoxicity Working Group reflects a consensus process based on expert opinion, supported by a narrative review of the scientific literature and recently published recommendations regarding audiologic management of children receiving cisplatin chemotherapy. We advocate that ototoxicity monitoring be recognized as standard of care for every child receiving cisplatin and incorporated into pediatric cancer treatment protocols. This paper proposes a minimum benchmark for the audiologic management of children undergoing cisplatin chemotherapy; a standard that can be readily implemented in most clinical settings worldwide.
SN - 2234-943X
ER -