Skip to content
DraconiticResearch
Search Sources API
203,234 studies31 sourcesUpdated 20 min ago
Peer-reviewedCC BY 4.0Journal of Clinical Medicine

Hospital Costs and Pleural Complications of Electromagnetic Navigational Bronchoscopy Versus CT-Guided Transthoracic Needle Biopsy: A German Multicentre Matched Analysis

  • Jacopo Saccomanno1
  • Martin Witzenrath1,2,3
  • Nikolaj Frost1
  • Ralf Hammerich4
  • Thomas Elgeti5
  • Susanne Lang6
  • Carolin Kraska6
  • Dominic Dellweg3,7
  • Patrick Parschke8
  • Daniel Drömann9,10
  • Goran Mitkovski10
  • Konrad Wetzer11
8 more authors
  • Olaf Schega11
  • Stephanie Burian12
  • Stefan Morgenstern13
  • Burkhard Bewig14
  • Karina Kleinschnitz15
  • Wolfgang Heinlein15
  • Markus Rathmayer15
  • Ralf-Harto Hübner1
15 affiliations
  1. 1Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany
  2. 2German Center for Lung Research (DZL), 10117 Berlin, Germany
  3. 3Capnetz Foundation, 30625 Hannover, Germany
  4. 4Administrative Office for Clinical Quality and Risk Management, Charité–Universitätsmedizin Berlin, 10117 Berlin, Germany
  5. 5Department of Radiology, Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 12203 Berlin, Germany
  6. 6Medizinische Klinik V, Universitätsklinikum Jena, 07747 Jena, Germany
  7. 7Klinik für Innere Medizin, Pneumologie und Gastroenterologie, Pius-Hospital Oldenburg, 26121 Oldenburg, Germany
  8. 8Medizinische Klinik III, Universitätsklinikum Schleswig-Holstein (UKSH), 23538 Lübeck, Germany
  9. 9Airway Research Center North (ARCN), German Center for Lung Research (DZL), 23538 Lübeck, Germany
  10. 10Klinik für Pneumologie und Intensivmedizin, Klinikum St. Georg Leipzig, 04129 Leipzig, Germany
  11. 11Fachklinik Pneumologie, Thoraxchirurgie und Allergologie, Johanniterkrankenhaus Treuenbrietzen, 14929 Treuenbrietzen, Germany
  12. 12Klinik für Pneumologie, Infektiologie und Internistische Intensivmedizin, Klinikum Dortmund, 44145 Dortmund, Germany
  13. 13Klinik für Pneumologie, Allergologie, Schlaf- und Beatmungsmedizin, Evangelische Kliniken Essen-Mitte gGmbH, 45276 Essen, Germany
  14. 14Medizinische Klinik, Städtisches Krankenhaus Kiel, 24116 Kiel, Germany
  15. 15Inspiring-Health GmbH, 80935 Munich, Germany
Open at sourceDOICite

Abstract

Background/Objectives: Electromagnetic navigational bronchoscopy (ENB) and CT-guided transthoracic needle biopsy (TTNB) are established approaches to sampling peripheral pulmonary lesions. Comparative real-world data on procedure-associated pleural complications and hospital resource use remain limited. We compared coded pleural complications, length of stay, hospital costs and reimbursement after ENB versus TTNB in German inpatient care. Methods: This retrospective multicentre analysis used fully anonymised administrative hospital cost and reimbursement data from nine German hospitals between January 2023 and December 2024. Of 2904 inpatient cases (590 ENB and 2314 TTNB), 536 matched pairs were generated by 1:1 nearest-neighbour propensity-score matching without replacement using age and sex, with exact matching on adjacent diagnosis-related group (ADRG2). Outcomes were coded pneumothorax, coded pneumothorax requiring chest-tube drainage, length of stay, total hospital costs and reimbursement. Results: In the matched cohort, mean age was 68.2 ± 10.6 years after TTNB and 68.5 ± 10.4 years after ENB; the male-to-female ratio was 1.34 and 1.36, respectively. Coded pneumothorax occurred less frequently after ENB than after TTNB (4.1% vs. 13.1%); in matched-pair logistic regression, ENB was associated with lower odds of coded pneumothorax (OR 0.28, 95% CI 0.17–0.47; p < 0.001). Coded pneumothorax requiring chest-tube drainage occurred in 3.4% versus 12.9%, respectively. Median length of stay was shorter after ENB (2 [IQR 1–4] vs. 3 [1–8] days; p < 0.001), whereas median hospital costs were higher (€5793 [4670–7466] vs. €3739 [1995–7514]; p < 0.001). Median reimbursement was €3366 in both groups (p = 0.186). Conclusions: In this German inpatient cohort, ENB was associated with fewer coded pleural complications and shorter hospital stays than TTNB, but with higher hospital costs despite similar reimbursement. These findings characterise system-specific inpatient resource use and do not establish comparative clinical superiority or cost-effectiveness.

Related

  1. Electromagnetic navigation bronchoscopy-guided three-dimensional conformal microwave ablation for unresectable peripheral high-risk pulmonary nodules: a mid-term assessment with no real-time intraoperative CT/cone-beam computed tomography guidance
    Yawei Liu, Yan Huang, Xiaodan Lin +7
    Translational Lung Cancer ResearchPeer-reviewedCC BY-NC-NDFull textOncologyEurope PMC
  2. Effectiveness and major bleeding complications with venoarterial extracorporeal membrane oxygenation in category E pulmonary thromboembolism: a multicentre retrospective study
    Jian Wang, Xiaohui Wang, Hong Chen +7
    BMJ Open Respiratory ResearchPeer-reviewedCC BYFull textGeneral medicineDOAJ
  3. Disease burden of rotavirus infection and its complications among children under 14 years old with acute gastroenteritis in China: a multicentre and retrospective study
    Shanshan Zhang, Chunli Li, Yongyu Su +24
    Emerging Microbes and InfectionsPeer-reviewedCC BYFull textInfectious diseaseDOAJ
  4. Feasibility and Safety of Transthoracic Echocardiography–Guided Transvenous Permanent Pacemaker Implantation Without Fluoroscopy
    JACC. AdvancesPeer-reviewedCC BYFull textCardiovascular medicineEurope PMC
  5. Transthoracic echocardiography vs. cardiac magnetic resonance imaging for the diagnosis of left ventricular thrombus: an updated systematic review and diagnostic accuracy meta-analysis
    European heart journal. Imaging methods and practicePeer-reviewedCC BYFull textGeneral medicineEurope PMC

Cite

BibTeXRIS
BibTeX
@article{saccomanno2026hospital,
  title = {{Hospital Costs and Pleural Complications of Electromagnetic Navigational Bronchoscopy Versus CT-Guided Transthoracic Needle Biopsy: A German Multicentre Matched Analysis}},
  author = {Jacopo Saccomanno and Martin Witzenrath and Nikolaj Frost and Ralf Hammerich and Thomas Elgeti and Susanne Lang and Carolin Kraska and Dominic Dellweg and Patrick Parschke and Daniel Drömann and Goran Mitkovski and Konrad Wetzer and Olaf Schega and Stephanie Burian and Stefan Morgenstern and Burkhard Bewig and Karina Kleinschnitz and Wolfgang Heinlein and Markus Rathmayer and Ralf-Harto Hübner},
  journal = {Journal of Clinical Medicine},
  year = {2026},
  month = nov,
  doi = {10.3390/jcm15218648},
  url = {https://www.mdpi.com/2077-0383/15/21/8648},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Hospital Costs and Pleural Complications of Electromagnetic Navigational Bronchoscopy Versus CT-Guided Transthoracic Needle Biopsy: A German Multicentre Matched Analysis
AU  - Jacopo Saccomanno
AU  - Martin Witzenrath
AU  - Nikolaj Frost
AU  - Ralf Hammerich
AU  - Thomas Elgeti
AU  - Susanne Lang
AU  - Carolin Kraska
AU  - Dominic Dellweg
AU  - Patrick Parschke
AU  - Daniel Drömann
AU  - Goran Mitkovski
AU  - Konrad Wetzer
AU  - Olaf Schega
AU  - Stephanie Burian
AU  - Stefan Morgenstern
AU  - Burkhard Bewig
AU  - Karina Kleinschnitz
AU  - Wolfgang Heinlein
AU  - Markus Rathmayer
AU  - Ralf-Harto Hübner
PY  - 2026
DA  - 2026/11/06
JO  - Journal of Clinical Medicine
DO  - 10.3390/jcm15218648
UR  - https://www.mdpi.com/2077-0383/15/21/8648
AB  - Background/Objectives: Electromagnetic navigational bronchoscopy (ENB) and CT-guided transthoracic needle biopsy (TTNB) are established approaches to sampling peripheral pulmonary lesions. Comparative real-world data on procedure-associated pleural complications and hospital resource use remain limited. We compared coded pleural complications, length of stay, hospital costs and reimbursement after ENB versus TTNB in German inpatient care. Methods: This retrospective multicentre analysis used fully anonymised administrative hospital cost and reimbursement data from nine German hospitals between January 2023 and December 2024. Of 2904 inpatient cases (590 ENB and 2314 TTNB), 536 matched pairs were generated by 1:1 nearest-neighbour propensity-score matching without replacement using age and sex, with exact matching on adjacent diagnosis-related group (ADRG2). Outcomes were coded pneumothorax, coded pneumothorax requiring chest-tube drainage, length of stay, total hospital costs and reimbursement. Results: In the matched cohort, mean age was 68.2 ± 10.6 years after TTNB and 68.5 ± 10.4 years after ENB; the male-to-female ratio was 1.34 and 1.36, respectively. Coded pneumothorax occurred less frequently after ENB than after TTNB (4.1% vs. 13.1%); in matched-pair logistic regression, ENB was associated with lower odds of coded pneumothorax (OR 0.28, 95% CI 0.17–0.47; p < 0.001). Coded pneumothorax requiring chest-tube drainage occurred in 3.4% versus 12.9%, respectively. Median length of stay was shorter after ENB (2 [IQR 1–4] vs. 3 [1–8] days; p < 0.001), whereas median hospital costs were higher (€5793 [4670–7466] vs. €3739 [1995–7514]; p < 0.001). Median reimbursement was €3366 in both groups (p = 0.186). Conclusions: In this German inpatient cohort, ENB was associated with fewer coded pleural complications and shorter hospital stays than TTNB, but with higher hospital costs despite similar reimbursement. These findings characterise system-specific inpatient resource use and do not establish comparative clinical superiority or cost-effectiveness.
SN  - 2077-0383
ER  -