Tobacco craving and suicidal risk in a cohort of subjects with schizophrenia: results from the national FACE-SZ cohort
Abstract
BACKGROUND: Tobacco use is highly prevalent among individuals with schizophrenia and exacerbates craving, a key METHODS: Data were collected from 1769 patients within the FondaMental Expert Centers for Schizophrenia network. Sociodemographic, clinical, addictive, suicidal, and treatment-related variables were analyzed using both univariate and multivariate logistic regression models. Mediation analyses were performed to ensure robust statistical inference. RESULTS: The prevalence of tobacco smoking was 52.8% (n = 878). Higher tobacco craving scores were significantly correlated with increased suicidal ideation (p = 0.004), more frequent suicide attempts (p < 0.001), and higher suicide scores (p < 0.001). In the multivariable analysis, no significant associations were found between craving scores and all suicide outcomes. Regression models confirmed a strong association between tobacco craving and lifetime alcohol use disorder (AUD) (p < 0.001). Mediation analyses showed that AUD does not mediate the craving-suicide relationship (indirect effects p > 0.05). CONCLUSIONS: These findings highlight the complex interplay between clinical severity, substance use, and suicidality in shaping craving levels among patients with schizophrenia. Mediation analyses showed that AUD does not explain the craving-suicide relationship, indicating that these represent separate, parallel risk pathways. Assessment of tobacco craving and comorbid substance use, particularly AUD, is essential when assessing suicide risk. These findings have important implications for suicide prevention and treatment strategies in individuals with schizophrenia and co-occurring substance use disorders.
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BibTeX
@article{tessier2026tobacco,
title = {{Tobacco craving and suicidal risk in a cohort of subjects with schizophrenia: results from the national FACE-SZ cohort}},
author = {Arnaud Tessier and Mélina Fatseas and Yecodji Dansou and Ophélia Godin and Fabrice Berna and Delphine Capdevielle and Cristobal Belmonte and Isabelle Chereau and Pierre-Michel Llorca and Nathalie Coulon and Sylvain Leigner and Thierry d'Amato and Romain Rey and Caroline Dubertret and Guillaume Fond and Laurent Boyer and Christine Passerieux and Mathieu Urbach and Baptiste Pignon and Franck Schürhoff and Andrei Szöke and Jasmina Mallet and David Misdrahi and M Andre and C Andrieu-Haller and A Ascarain and F Berna and O Blanc and E Bourguignon and D Capdevielle and M Cléry and I Chereau-Boudet and J Clauss-Kobayashi and N Coulon and R Dassing and Jm Dorey and J Dubos and C Dubertret and A Esselin and E Fakra and G Fond and F Gabayet and M Jarroir and D Lacelle and M Leboyer and S Leignier and Pm Llorca and J Mallet and E Metairie and T Michel and D Misdrahi and C Passerieux and B Pignon and P Peri and C Portalier and R Rey and C Roman and E Salvat and B Schorr and F Schürhoff},
journal = {Psychiatry Research},
year = {2026},
month = oct,
doi = {10.1016/j.psychres.2026.117028},
url = {https://u-bordeaux.hal.science/hal-05801570v1},
note = {CC BY},
}
RIS
TY - JOUR
TI - Tobacco craving and suicidal risk in a cohort of subjects with schizophrenia: results from the national FACE-SZ cohort
AU - Arnaud Tessier
AU - Mélina Fatseas
AU - Yecodji Dansou
AU - Ophélia Godin
AU - Fabrice Berna
AU - Delphine Capdevielle
AU - Cristobal Belmonte
AU - Isabelle Chereau
AU - Pierre-Michel Llorca
AU - Nathalie Coulon
AU - Sylvain Leigner
AU - Thierry d'Amato
AU - Romain Rey
AU - Caroline Dubertret
AU - Guillaume Fond
AU - Laurent Boyer
AU - Christine Passerieux
AU - Mathieu Urbach
AU - Baptiste Pignon
AU - Franck Schürhoff
AU - Andrei Szöke
AU - Jasmina Mallet
AU - David Misdrahi
AU - M Andre
AU - C Andrieu-Haller
AU - A Ascarain
AU - F Berna
AU - O Blanc
AU - E Bourguignon
AU - D Capdevielle
AU - M Cléry
AU - I Chereau-Boudet
AU - J Clauss-Kobayashi
AU - N Coulon
AU - R Dassing
AU - Jm Dorey
AU - J Dubos
AU - C Dubertret
AU - A Esselin
AU - E Fakra
AU - G Fond
AU - F Gabayet
AU - M Jarroir
AU - D Lacelle
AU - M Leboyer
AU - S Leignier
AU - Pm Llorca
AU - J Mallet
AU - E Metairie
AU - T Michel
AU - D Misdrahi
AU - C Passerieux
AU - B Pignon
AU - P Peri
AU - C Portalier
AU - R Rey
AU - C Roman
AU - E Salvat
AU - B Schorr
AU - F Schürhoff
PY - 2026
DA - 2026/10/15
JO - Psychiatry Research
DO - 10.1016/j.psychres.2026.117028
UR - https://u-bordeaux.hal.science/hal-05801570v1
AB - BACKGROUND: Tobacco use is highly prevalent among individuals with schizophrenia and exacerbates craving, a key METHODS: Data were collected from 1769 patients within the FondaMental Expert Centers for Schizophrenia network. Sociodemographic, clinical, addictive, suicidal, and treatment-related variables were analyzed using both univariate and multivariate logistic regression models. Mediation analyses were performed to ensure robust statistical inference. RESULTS: The prevalence of tobacco smoking was 52.8% (n = 878). Higher tobacco craving scores were significantly correlated with increased suicidal ideation (p = 0.004), more frequent suicide attempts (p < 0.001), and higher suicide scores (p < 0.001). In the multivariable analysis, no significant associations were found between craving scores and all suicide outcomes. Regression models confirmed a strong association between tobacco craving and lifetime alcohol use disorder (AUD) (p < 0.001). Mediation analyses showed that AUD does not mediate the craving-suicide relationship (indirect effects p > 0.05). CONCLUSIONS: These findings highlight the complex interplay between clinical severity, substance use, and suicidality in shaping craving levels among patients with schizophrenia. Mediation analyses showed that AUD does not explain the craving-suicide relationship, indicating that these represent separate, parallel risk pathways. Assessment of tobacco craving and comorbid substance use, particularly AUD, is essential when assessing suicide risk. These findings have important implications for suicide prevention and treatment strategies in individuals with schizophrenia and co-occurring substance use disorders.
SN - 0165-1781
SN - 1872-7123
ER -