Transdiagnostic and clinical predictors of longitudinal misophonia symptoms.
- 1Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States.
- 2Department of Psychology, University of Mississippi, University, MS, United States.
- 3Analytics, Harrisburg University of Science and Technology, Harrisburg, PA, United States.
Abstract
Introduction
Anxiety sensitivity (AS) and distress tolerance (DT) are emotional-vulnerability factors driving emotion dysregulation. AS and DT may amplify misophonia. Research examining transdiagnostic factors predicting misophonia is largely cross-sectional. We examined relations between AS, DT, and longitudinal misophonia symptoms, adjusting for clinical variables.Methods
Fifty-eight individuals recruited from soQuiet endorsing clinical misophonia symptoms completed baseline and daily surveys 3x daily for 30 days.Results
Bivariate analyses suggested baseline AS was associated with elevated longitudinal misophonia symptoms during and not during triggers, while baseline DT was associated with higher misophonia symptoms during triggers. Baseline AS, momentary emotion dysregulation, and baseline misophonia were predictors of longitudinal misophonia during triggers, adjusting for momentary emotion dysregulation, baseline misophonia, and baseline obsessions and compulsions. An alpha correction suggested an attenuated AS effect. Null effects for DT may be explained by analyses supporting emotion dysregulation as a mediator of the relation between DT and misophonia. Effects of obsessive-compulsive symptoms were null.Discussion
Results inform longitudinal relations between transdiagnostic factors and misophonia. A predominant limitation is sample homogeneity. Misophonia symptom fluctuations appear contextualized, likely impacted by environmental and emotional-vulnerability factors. Results inform ongoing advancements to misophonia assessment and, pending further investigation, clinical interventions targeting malleable transdiagnostic factors.
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BibTeX
@article{pavlacic2026transdiagnostic,
title = {{Transdiagnostic and clinical predictors of longitudinal misophonia symptoms.}},
author = {Jeffrey M Pavlacic and Averi N Gaines and Sara M Witcraft and Allie Freshley and Erin M Buchanan and Bernadette Cortese and Christopher Sege and Alyssa A Rheingold and Thomas Uhde and Laura J Dixon},
journal = {Frontiers in cognition},
year = {2026},
month = oct,
doi = {10.3389/fcogn.2026.1945899},
url = {https://europepmc.org/article/MED/42898149},
note = {CC BY},
}
RIS
TY - JOUR
TI - Transdiagnostic and clinical predictors of longitudinal misophonia symptoms.
AU - Jeffrey M Pavlacic
AU - Averi N Gaines
AU - Sara M Witcraft
AU - Allie Freshley
AU - Erin M Buchanan
AU - Bernadette Cortese
AU - Christopher Sege
AU - Alyssa A Rheingold
AU - Thomas Uhde
AU - Laura J Dixon
PY - 2026
DA - 2026/10/05
JO - Frontiers in cognition
DO - 10.3389/fcogn.2026.1945899
UR - https://europepmc.org/article/MED/42898149
AB - Introduction Anxiety sensitivity (AS) and distress tolerance (DT) are emotional-vulnerability factors driving emotion dysregulation. AS and DT may amplify misophonia. Research examining transdiagnostic factors predicting misophonia is largely cross-sectional. We examined relations between AS, DT, and longitudinal misophonia symptoms, adjusting for clinical variables.Methods Fifty-eight individuals recruited from soQuiet endorsing clinical misophonia symptoms completed baseline and daily surveys 3x daily for 30 days.Results Bivariate analyses suggested baseline AS was associated with elevated longitudinal misophonia symptoms during and not during triggers, while baseline DT was associated with higher misophonia symptoms during triggers. Baseline AS, momentary emotion dysregulation, and baseline misophonia were predictors of longitudinal misophonia during triggers, adjusting for momentary emotion dysregulation, baseline misophonia, and baseline obsessions and compulsions. An alpha correction suggested an attenuated AS effect. Null effects for DT may be explained by analyses supporting emotion dysregulation as a mediator of the relation between DT and misophonia. Effects of obsessive-compulsive symptoms were null.Discussion Results inform longitudinal relations between transdiagnostic factors and misophonia. A predominant limitation is sample homogeneity. Misophonia symptom fluctuations appear contextualized, likely impacted by environmental and emotional-vulnerability factors. Results inform ongoing advancements to misophonia assessment and, pending further investigation, clinical interventions targeting malleable transdiagnostic factors.
SN - 2813-4532
ER -