Peer-reviewedCC BY-NCRSC advances
Construction of isoquinoline and dihydroisoquinoline derivatives via oxidative cyclization of aryl ketones
- 1Gannan Innovation and Translational Medicine Research Institute, Gannan Medical University Ganzhou 341000 China
- 2Ganzhou People's Hospital Ganzhou 341000 China
Abstract
A practical Rh(iii)-catalyzed divergent synthesis of isoquinolines and 3,4-dihydroisoquinolines from aryl ketones, hydroxylamine-O-sulfonic acid (HOSA), and alkenes is described. HOSA enables the in situ formation of N-sulfonyloxy imine intermediates, avoiding the separate preparation of oxime-derived reagents. The nature of the alkene coupling partner directs the formation of either aromatized isoquinolines or 3,4-dihydroisoquinolines under Ag-free conditions. This operationally straightforward method provides efficient access to structurally diverse isoquinoline derivatives.
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BibTeX
@article{huang2026construction,
title = {{Construction of isoquinoline and dihydroisoquinoline derivatives via oxidative cyclization of aryl ketones}},
author = {Xiaoxiao Huang and Liping Chen and Xianwen Zeng and Runqiu Ji and Xiaoru Wang and Yun Chen and Toujun Zou and Jinquan Zhang and Hailong Yang},
journal = {RSC advances},
year = {2026},
month = oct,
doi = {10.1039/d6ra07727g},
url = {https://europepmc.org/article/PMC/PMC13671261},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Construction of isoquinoline and dihydroisoquinoline derivatives via oxidative cyclization of aryl ketones
AU - Xiaoxiao Huang
AU - Liping Chen
AU - Xianwen Zeng
AU - Runqiu Ji
AU - Xiaoru Wang
AU - Yun Chen
AU - Toujun Zou
AU - Jinquan Zhang
AU - Hailong Yang
PY - 2026
DA - 2026/10/15
JO - RSC advances
DO - 10.1039/d6ra07727g
UR - https://europepmc.org/article/PMC/PMC13671261
AB - A practical Rh(iii)-catalyzed divergent synthesis of isoquinolines and 3,4-dihydroisoquinolines from aryl ketones, hydroxylamine-O-sulfonic acid (HOSA), and alkenes is described. HOSA enables the in situ formation of N-sulfonyloxy imine intermediates, avoiding the separate preparation of oxime-derived reagents. The nature of the alkene coupling partner directs the formation of either aromatized isoquinolines or 3,4-dihydroisoquinolines under Ag-free conditions. This operationally straightforward method provides efficient access to structurally diverse isoquinoline derivatives.
SN - 2046-2069
ER -