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PreprintCC BYChemRxiv

Dramatic acceleration by silica gel under highly concentrated conditions: Aromatic halogenation and nitroaldol (Henry) reactions

  • Kiyoshi Tanemura1,2
  1. 1School of Life Dentistry at Niigata
  2. 2Nippon Dental University
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Abstract

Dramatic acceleration of aromatic halogenation and nitroaldol (Henry) reactions was achieved by the addition of silica gel under highly concentrated conditions. Bromination, chlorination, and iodination of various aromatic substrates were examined in the presence of silica gel under highly concentrated conditions, and significant acceleration was observed for many substrates compared with conventional conditions. The combination of silica gel and highly concentrated conditions also markedly accelerated nitroaldol (Henry) reactions of aliphatic and aromatic aldehydes. Silica gel could be recovered and reused in both halogenation and nitroaldol reactions without significant loss of activity. These results demonstrate a simple, efficient, and more sustainable protocol for promoting important organic transformations.

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Cite

BibTeXRIS
BibTeX
@misc{tanemura2026dramatic,
  title = {{Dramatic acceleration by silica gel under highly concentrated conditions: Aromatic halogenation and nitroaldol (Henry) reactions}},
  author = {Kiyoshi Tanemura},
  howpublished = {ChemRxiv},
  year = {2026},
  month = sep,
  doi = {10.26434/chemrxiv.15008289/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008289/v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - Dramatic acceleration by silica gel under highly concentrated conditions: Aromatic halogenation and nitroaldol (Henry) reactions
AU  - Kiyoshi Tanemura
PY  - 2026
DA  - 2026/09/04
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15008289/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008289/v1
AB  - Dramatic acceleration of aromatic halogenation and nitroaldol (Henry) reactions was achieved by the addition of silica gel under highly concentrated conditions. Bromination, chlorination, and iodination of various aromatic substrates were examined in the presence of silica gel under highly concentrated conditions, and significant acceleration was observed for many substrates compared with conventional conditions. The combination of silica gel and highly concentrated conditions also markedly accelerated nitroaldol (Henry) reactions of aliphatic and aromatic aldehydes. Silica gel could be recovered and reused in both halogenation and nitroaldol reactions without significant loss of activity. These results demonstrate a simple, efficient, and more sustainable protocol for promoting important organic transformations.
ER  -