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Peer-reviewedCC BY 4.0PLOS Pathogens

Suramin inspires next-generation broad-spectrum antiviral design targeting RdRps

  • Arwen Baer1
  • Ge Yang2
  • Fan Bu3
  • Bin Liu
  1. 1Section of Transcription & Gene Regulation, The Hormel Institute, University of Minnesota, Austin, Minnesota, United States of America
  2. 2Department of Chemistry, Gustavus Adolphus College, St Peter, Minnesota, United States of America
  3. 3Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America
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Abstract

Structural studies of diverse viral RNA-dependent RNA polymerases reveal that the broad-spectrum antiviral Suramin binds distinct sites while repeatedly exploiting conserved RNA-interacting and electrostatic features. This Pearl highlights common vulnerabilities within viral RNA polymerases and discusses how structural studies provide a framework for future antiviral design.

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Cite

BibTeXRIS
BibTeX
@article{baer2026suramin,
  title = {{Suramin inspires next-generation broad-spectrum antiviral design targeting RdRps}},
  author = {Arwen Baer and Ge Yang and Fan Bu and Bin Liu},
  journal = {PLOS Pathogens},
  year = {2026},
  month = nov,
  doi = {10.1371/journal.ppat.1014766},
  url = {https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1014766},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Suramin inspires next-generation broad-spectrum antiviral design targeting RdRps
AU  - Arwen Baer
AU  - Ge Yang
AU  - Fan Bu
AU  - Bin Liu
PY  - 2026
DA  - 2026/11/06
JO  - PLOS Pathogens
DO  - 10.1371/journal.ppat.1014766
UR  - https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1014766
AB  - Structural studies of diverse viral RNA-dependent RNA polymerases reveal that the broad-spectrum antiviral Suramin binds distinct sites while repeatedly exploiting conserved RNA-interacting and electrostatic features. This Pearl highlights common vulnerabilities within viral RNA polymerases and discusses how structural studies provide a framework for future antiviral design.
SN  - 1553-7374
ER  -