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Peer-reviewedCC BY-NC-NDTranslational stroke research

High Spatial Resolution ²³Na-MRI for Ischemic Brain Injury Detection.

  • Yuanyuan Jiang1
  • Xiaoqing Alice Zhou1
  • Takahiko Imai2
  • Lydia Hawley2
  • David Hike1
  • Sohail Mohammed1
  • Grace Yu1
  • Cenk Ayata2
  • David Y Chung2
  • Xin Yu3
  1. 1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
  2. 2Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
  3. 3Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA. [email protected].
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Abstract

High spatial resolution sodium (²³Na) imaging of brain lesions remains challenging due to the intrinsically low signal-to-noise ratio (SNR) of ²³Na-MRI compared with conventional proton (¹H) MRI. In this preclinical mouse study, we developed a high-resolution ²³Na-MRI platform based on a 14 T preclinical scanner using a dual-tuned head-implanted RF coil. This implanted coil configuration enabled longitudinal multimodal imaging in the same animal, including 1¹H-based T₂-weighted anatomical and diffusion-weighted imaging (DWI), and high-resolution ²³Na-MRI. To evaluate the capability of this approach for detecting acute ischemic injury, ischemic stroke was induced in mice using the middle cerebral artery occlusion (MCAO) model. Brain-wide ²³Na-MRI was acquired within the first 4 hours following MCAO at an in-plane resolution of 300 × 300 µm². Hyperintense ²³Na-MRI signals were observed in the ischemic brain regions, presenting a contrast-to-noise ratio (CNR) that exceeded that of T₂-weighted images. Infarct regions can be well identified by elevated ²³Na-MRI signal, which is spatially consistent with regions of reduced apparent diffusion coefficient (ADC) values, indicating water restriction in the ischemic core. This work established implanted dual-tuned ¹H/²³Na RF coils as a powerful approach for high-resolution ²³Na-MRI readout, facilitating the early detection of ischemic brain injury.

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Cite

BibTeXRIS
BibTeX
@article{jiang2026high,
  title = {{High Spatial Resolution ²³Na-MRI for Ischemic Brain Injury Detection.}},
  author = {Yuanyuan Jiang and Xiaoqing Alice Zhou and Takahiko Imai and Lydia Hawley and David Hike and Sohail Mohammed and Grace Yu and Cenk Ayata and David Y Chung and Xin Yu},
  journal = {Translational stroke research},
  year = {2026},
  month = oct,
  doi = {10.1007/s12975-026-01503-z},
  url = {https://europepmc.org/article/MED/42961728},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - High Spatial Resolution ²³Na-MRI for Ischemic Brain Injury Detection.
AU  - Yuanyuan Jiang
AU  - Xiaoqing Alice Zhou
AU  - Takahiko Imai
AU  - Lydia Hawley
AU  - David Hike
AU  - Sohail Mohammed
AU  - Grace Yu
AU  - Cenk Ayata
AU  - David Y Chung
AU  - Xin Yu
PY  - 2026
DA  - 2026/10/30
JO  - Translational stroke research
DO  - 10.1007/s12975-026-01503-z
UR  - https://europepmc.org/article/MED/42961728
AB  - High spatial resolution sodium (²³Na) imaging of brain lesions remains challenging due to the intrinsically low signal-to-noise ratio (SNR) of ²³Na-MRI compared with conventional proton (¹H) MRI. In this preclinical mouse study, we developed a high-resolution ²³Na-MRI platform based on a 14 T preclinical scanner using a dual-tuned head-implanted RF coil. This implanted coil configuration enabled longitudinal multimodal imaging in the same animal, including 1¹H-based T₂-weighted anatomical and diffusion-weighted imaging (DWI), and high-resolution ²³Na-MRI. To evaluate the capability of this approach for detecting acute ischemic injury, ischemic stroke was induced in mice using the middle cerebral artery occlusion (MCAO) model. Brain-wide ²³Na-MRI was acquired within the first 4 hours following MCAO at an in-plane resolution of 300 × 300 µm². Hyperintense ²³Na-MRI signals were observed in the ischemic brain regions, presenting a contrast-to-noise ratio (CNR) that exceeded that of T₂-weighted images. Infarct regions can be well identified by elevated ²³Na-MRI signal, which is spatially consistent with regions of reduced apparent diffusion coefficient (ADC) values, indicating water restriction in the ischemic core. This work established implanted dual-tuned ¹H/²³Na RF coils as a powerful approach for high-resolution ²³Na-MRI readout, facilitating the early detection of ischemic brain injury.
SN  - 1868-4483
SN  - 1868-601X
ER  -