Karyotypic complexity and mutated TP53 are associated with myeloid neoplasms with ring chromosomes.
- 1Hospital Israelita Albert Einstein, Sao Paulo, SP, Brazil. Electronic address: [email protected].
- 2Hospital Israelita Albert Einstein, Sao Paulo, SP, Brazil.
- 3Hospital Israelita Albert Einstein, Sao Paulo, SP, Brazil; Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, SP, Brazil.
Abstract
Introduction
This study evaluated the prevalence of ring chromosomes, their association with TP53 alterations, and their prognostic impact in myeloid neoplasms.Methods
A retrospective analysis of 12,935 onco-hematological karyotypes from 2017-2022 identified 21 adult patients with myeloid neoplasms harboring ring chromosomes. Fluorescence in situ hybridization was used to assess TP53 deletions, while next-generation sequencing detected TP53 mutations.Results
Ring chromosomes were identified in 0.29% of the cases. The median patient age was 69 years and 67% were male. Acute myeloid leukemia and myelodysplastic neoplasms were the most frequent diagnoses. The median number of karyotypic abnormalities was nine (range: 1-28). Karyotypic complexity, TP53 deletions, mutations, and multi-hit alterations were observed in 81%, 19%, 78%, and 61% of the cases, respectively. ring chromosomes were most frequently derived from chromosomes 6 and 7. Median overall survival was 3.2 months. TP53 multi-hit alterations (Hazard ratio: 10.63; p-value = 0.001) and the number of karyotypic abnormalities (Hazard ratio: 1.06; p-value = 0.043) were significantly associated with increased mortality. Patients with very complex karyotypes had a 5.53-fold higher risk of death.Conclusion
Ring chromosomes are rare in myeloid neoplasms and are consistently associated with high karyotypic complexity and TP53 alterations. In this cohort, both TP53 alterations and karyotypic complexity emerged as independent prognostic factors and were strongly associated with an extremely poor prognosis.
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BibTeX
@article{santos2026karyotypic,
title = {{Karyotypic complexity and mutated TP53 are associated with myeloid neoplasms with ring chromosomes.}},
author = {Thaís Gonçalves Dos Santos and Mauren Fernanda Moller Dos Santos and Renata Kiyomi Kishimoto and Daniela Borri and Caroline Nunes Silveira and Susana Elaine Alves Rosa and Luiz Gustavo Ferreira Cortes and Paulo Campregher and Elvira Deolinda Rodrigues Pereira Velloso},
journal = {Hematology, transfusion and cell therapy},
year = {2026},
month = oct,
doi = {10.1016/j.htct.2026.108544},
url = {https://europepmc.org/article/MED/42842953},
note = {CC BY},
}
RIS
TY - JOUR
TI - Karyotypic complexity and mutated TP53 are associated with myeloid neoplasms with ring chromosomes.
AU - Thaís Gonçalves Dos Santos
AU - Mauren Fernanda Moller Dos Santos
AU - Renata Kiyomi Kishimoto
AU - Daniela Borri
AU - Caroline Nunes Silveira
AU - Susana Elaine Alves Rosa
AU - Luiz Gustavo Ferreira Cortes
AU - Paulo Campregher
AU - Elvira Deolinda Rodrigues Pereira Velloso
PY - 2026
DA - 2026/10/07
JO - Hematology, transfusion and cell therapy
DO - 10.1016/j.htct.2026.108544
UR - https://europepmc.org/article/MED/42842953
AB - Introduction This study evaluated the prevalence of ring chromosomes, their association with TP53 alterations, and their prognostic impact in myeloid neoplasms.Methods A retrospective analysis of 12,935 onco-hematological karyotypes from 2017-2022 identified 21 adult patients with myeloid neoplasms harboring ring chromosomes. Fluorescence in situ hybridization was used to assess TP53 deletions, while next-generation sequencing detected TP53 mutations.Results Ring chromosomes were identified in 0.29% of the cases. The median patient age was 69 years and 67% were male. Acute myeloid leukemia and myelodysplastic neoplasms were the most frequent diagnoses. The median number of karyotypic abnormalities was nine (range: 1-28). Karyotypic complexity, TP53 deletions, mutations, and multi-hit alterations were observed in 81%, 19%, 78%, and 61% of the cases, respectively. ring chromosomes were most frequently derived from chromosomes 6 and 7. Median overall survival was 3.2 months. TP53 multi-hit alterations (Hazard ratio: 10.63; p-value = 0.001) and the number of karyotypic abnormalities (Hazard ratio: 1.06; p-value = 0.043) were significantly associated with increased mortality. Patients with very complex karyotypes had a 5.53-fold higher risk of death.Conclusion Ring chromosomes are rare in myeloid neoplasms and are consistently associated with high karyotypic complexity and TP53 alterations. In this cohort, both TP53 alterations and karyotypic complexity emerged as independent prognostic factors and were strongly associated with an extremely poor prognosis.
SN - 2531-1379
SN - 2531-1387
ER -