Multifocal electroretinography assessment of retinal responses to myopic defocus lenses
4 affiliations
- 1Optometry Department, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia
- 2Optometry Department, East Jeddah General Hospital, Jeddah, Makkah, Saudi Arabia
- 3Ophthalmology Department, King Saud University Medical City, Riyadh, Saudi Arabia
- 4School of Optometry, University of California, Berkeley, CA, United States of America
Abstract
Aim: To evaluate the short-term retinal electrical responses elicited by defocus segment lenses in emmetropic eyes using multifocal electroretinography (mfERG).
Materials & Methods: A prospective cross-sectional study enrolled 14 young, healthy emmetropic participants aged 18 to 22 years with no ocular or systemic diseases. Comprehensive eye examinations were conducted, and mfERG recordings were obtained using six different condition scenarios. Retinal responses were analyzed across hexagon ring groupings defined by angular extent (Ring 1: 2.5°, Ring 2: 7.5°, Ring 3: 14°, Ring 4: 22°, Ring 5: 30°). Statistical analysis was performed to compare retinal responses across different lens types and retinal regions.
Results: No significant differences in retinal electrical responses were detected across the six lens conditions for negative (N1) latency (ms), positive (P1) latency (ms), or P1 amplitude (nV/deg ² ) (all p > 0.05). Regional variations in amplitude and latency across concentric retinal rings were observed but reflected expected normative mfERG gradients independent of lens type.
Conclusion: The tested defocus segment lens designs did not produce statistically detectable alterations in first order mfERG parameters in structurally intact emmetropic eyes under brief exposure. Although the analytical framework demonstrated sufficient sensitivity to identify medium to large electrophysiological effects, the current design may lack resolution for subtle retinal adaptations. Future investigations incorporating larger cohorts, prolonged optical exposure, and nonlinear analytical techniques in ametropic populations will be necessary to determine whether clinically relevant myopia control mechanisms correspond to measurable electrophysiological modulation.
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BibTeX
@article{alhazmi2026multifocal,
title = {{Multifocal electroretinography assessment of retinal responses to myopic defocus lenses}},
author = {Mohammed Alhazmi and Mohammed Althomali and Muteb Alanazi and Wafa Alotaibi and Eman Alghamdi and Ali Almustanyir and Fahd Alqahtani and Maria Liu},
journal = {PeerJ},
year = {2026},
month = oct,
doi = {10.7717/peerj.21766},
url = {https://peerj.com/articles/21766},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Multifocal electroretinography assessment of retinal responses to myopic defocus lenses
AU - Mohammed Alhazmi
AU - Mohammed Althomali
AU - Muteb Alanazi
AU - Wafa Alotaibi
AU - Eman Alghamdi
AU - Ali Almustanyir
AU - Fahd Alqahtani
AU - Maria Liu
PY - 2026
DA - 2026/10/05
JO - PeerJ
DO - 10.7717/peerj.21766
UR - https://peerj.com/articles/21766
AB - Aim: To evaluate the short-term retinal electrical responses elicited by defocus segment lenses in emmetropic eyes using multifocal electroretinography (mfERG). Materials & Methods: A prospective cross-sectional study enrolled 14 young, healthy emmetropic participants aged 18 to 22 years with no ocular or systemic diseases. Comprehensive eye examinations were conducted, and mfERG recordings were obtained using six different condition scenarios. Retinal responses were analyzed across hexagon ring groupings defined by angular extent (Ring 1: 2.5°, Ring 2: 7.5°, Ring 3: 14°, Ring 4: 22°, Ring 5: 30°). Statistical analysis was performed to compare retinal responses across different lens types and retinal regions. Results: No significant differences in retinal electrical responses were detected across the six lens conditions for negative (N1) latency (ms), positive (P1) latency (ms), or P1 amplitude (nV/deg ² ) (all p > 0.05). Regional variations in amplitude and latency across concentric retinal rings were observed but reflected expected normative mfERG gradients independent of lens type. Conclusion: The tested defocus segment lens designs did not produce statistically detectable alterations in first order mfERG parameters in structurally intact emmetropic eyes under brief exposure. Although the analytical framework demonstrated sufficient sensitivity to identify medium to large electrophysiological effects, the current design may lack resolution for subtle retinal adaptations. Future investigations incorporating larger cohorts, prolonged optical exposure, and nonlinear analytical techniques in ametropic populations will be necessary to determine whether clinically relevant myopia control mechanisms correspond to measurable electrophysiological modulation.
SN - 2167-8359
ER -