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Peer-reviewedCC BYBone Research

The gut-bone axis: impact of diet on gut microbiome and osteoporosis

  • Yue Wang1,2
  • Miao Xu3
  • Qinzuo Dong4
  • Xuan Lin1,5
  • Qiang Zhang1
  • Hua Shi6
  • Xiaoning Lin1,5
  • H Liu7
  • Min Yu8
  • Jianlin Shen9,10
10 affiliations
  1. 1Central Laboratory, Affiliated Hospital of Putian University, School of Basic Medicine, Putian University, Putian, Fujian, China
  2. 2Key Laboratory of Translational Tumor Medicine in Fujian Province, Putian University, Putian, Fujian, China
  3. 3School of Basic Medicine, Fujian Medical University, Fuzhou, Fujian, China
  4. 4First Clinical Medical College, Yunnan University of Chinese Medicine, Kunming, Yunnan, China
  5. 5Department of Orthopedics, Affiliated Hospital of Putian University, Putian, Fujian, China
  6. 6Second Clinical Medical College, Yunnan University of Chinese Medicine, Kunming, Yunnan, China
  7. 7Department of Orthopaedics, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China. [email protected]
  8. 8Department of General Surgery, Chongqing General Hospital, Chongqing University, Chongqing, China. [email protected]
  9. 9Central Laboratory, Affiliated Hospital of Putian University, School of Basic Medicine, Putian University, Putian, Fujian, China. [email protected]
  10. 10Department of Orthopedics, Affiliated Hospital of Putian University, Putian, Fujian, China. [email protected]
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Abstract

Osteoporosis, a global health challenge characterized by reduced bone mineral density (BMD) and increased fracture risk, is closely linked to interactions between dietary patterns and gut microbiota (GM). Recent advances in GM research highlight the gut-bone axis as a pivotal focus in osteoporosis studies, revealing that variations in dietary habits and nutrient intake differentially modulate GM composition and metabolic activity, thereby influencing skeletal health. This review synthesizes current evidence on the interplay between dietary practices, GM, and bone health, aiming to identify preventive and therapeutic strategies for osteoporosis management. Collectively, these findings underscore the potential of dietary interventions targeting GM modulation as a novel therapeutic approach, advocating for personalized nutritional strategies to improve skeletal health in high-risk populations.

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Cite

BibTeXRIS
BibTeX
@article{wang2026gutbone,
  title = {{The gut-bone axis: impact of diet on gut microbiome and osteoporosis}},
  author = {Yue Wang and Miao Xu and Qinzuo Dong and Xuan Lin and Qiang Zhang and Hua Shi and Xiaoning Lin and H Liu and Min Yu and Jianlin Shen},
  journal = {Bone Research},
  year = {2026},
  month = jun,
  doi = {10.1038/s41413-026-00550-4},
  url = {https://doi.org/10.1038/s41413-026-00550-4},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - The gut-bone axis: impact of diet on gut microbiome and osteoporosis
AU  - Yue Wang
AU  - Miao Xu
AU  - Qinzuo Dong
AU  - Xuan Lin
AU  - Qiang Zhang
AU  - Hua Shi
AU  - Xiaoning Lin
AU  - H Liu
AU  - Min Yu
AU  - Jianlin Shen
PY  - 2026
DA  - 2026/06/04
JO  - Bone Research
DO  - 10.1038/s41413-026-00550-4
UR  - https://doi.org/10.1038/s41413-026-00550-4
AB  - Osteoporosis, a global health challenge characterized by reduced bone mineral density (BMD) and increased fracture risk, is closely linked to interactions between dietary patterns and gut microbiota (GM). Recent advances in GM research highlight the gut-bone axis as a pivotal focus in osteoporosis studies, revealing that variations in dietary habits and nutrient intake differentially modulate GM composition and metabolic activity, thereby influencing skeletal health. This review synthesizes current evidence on the interplay between dietary practices, GM, and bone health, aiming to identify preventive and therapeutic strategies for osteoporosis management. Collectively, these findings underscore the potential of dietary interventions targeting GM modulation as a novel therapeutic approach, advocating for personalized nutritional strategies to improve skeletal health in high-risk populations.
SN  - 2095-4700
SN  - 2095-6231
ER  -