Novichok A-230: Monitoring of Provisional Airborne Exposure Levels
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Abstract
A method was developed to monitor vaporous Novichok A-230 using depot area air monitoring system (DAAMS) tubes packed with Tenax-TA sorbent, which were solvent-extracted with methanol; the extract was concentrated via nitrogen evaporation, then analyzed by LC-MS/MS. Provisional concentration values, or Z levels, of A-230 were extrapolated from the general population limit (GPL) airborne exposure levels of VX, due to A-230’s similarity to VX as a low–vapor-pressure nerve agent. This monitoring method was conducted in accordance with all quality control (QC) criteria set forth in the U.S. Army CASARM Quality Assurance Plan, with an average percent recovery of 88%, a limit of quantitation (LOQ) of 0.012 ng/mL, a target action limit (TAL) of 0.041 ng/mL, and an uncertainty in found mass (UIFM) of 16%.
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BibTeX
@article{grisham2026novichok,
title = {{Novichok A-230: Monitoring of Provisional Airborne Exposure Levels}},
author = {Charmel Grisham and Katelyn Koll and Sara Paalhar and Brad Gay and Becky Stilley and Noah Eichelberger and Melanie Deardorff and Cristina Youngren and Robinson Mikowlski and Evan Durnal},
journal = {ACS Omega},
year = {2026},
month = oct,
doi = {10.1021/acsomega.6c04043},
url = {https://pubs.acs.org/acsodf/article/11/42/64574/5449778/Novichok-A-230-Monitoring-of-Provisional-Airborne},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Novichok A-230: Monitoring of Provisional Airborne Exposure Levels
AU - Charmel Grisham
AU - Katelyn Koll
AU - Sara Paalhar
AU - Brad Gay
AU - Becky Stilley
AU - Noah Eichelberger
AU - Melanie Deardorff
AU - Cristina Youngren
AU - Robinson Mikowlski
AU - Evan Durnal
PY - 2026
DA - 2026/10/13
JO - ACS Omega
DO - 10.1021/acsomega.6c04043
UR - https://pubs.acs.org/acsodf/article/11/42/64574/5449778/Novichok-A-230-Monitoring-of-Provisional-Airborne
AB - A method was developed to monitor vaporous Novichok A-230 using depot area air monitoring system (DAAMS) tubes packed with Tenax-TA sorbent, which were solvent-extracted with methanol; the extract was concentrated via nitrogen evaporation, then analyzed by LC-MS/MS. Provisional concentration values, or Z levels, of A-230 were extrapolated from the general population limit (GPL) airborne exposure levels of VX, due to A-230’s similarity to VX as a low–vapor-pressure nerve agent. This monitoring method was conducted in accordance with all quality control (QC) criteria set forth in the U.S. Army CASARM Quality Assurance Plan, with an average percent recovery of 88%, a limit of quantitation (LOQ) of 0.012 ng/mL, a target action limit (TAL) of 0.041 ng/mL, and an uncertainty in found mass (UIFM) of 16%.
SN - 2470-1343
ER -