Inflammatory Markers and Outcomes After Liver Resection for Colorectal Liver Metastases.
- 1Liver Surgery Unit, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, São Paulo, Brazil.
- 2Bahiana School of Medicine and Public Health, Salvador, Bahia, Brazil.
Abstract
Background and objectives
The liver is the main site of colorectal metastatic disease. This study evaluated the association of Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), and Monocyte-to-Lymphocyte Ratio (MLR) among patients with colorectal liver metastases (CRLM) undergoing liver resection.Methods
A cohort of patients undergoing curative-intent liver resection for CRLM between 2009 and 2020 was evaluated. Association between inflammatory indices and overall survival (OS), disease-free survival (DFS), and postoperative morbidity and mortality were studied. Subgroup analyses included patients undergoing major hepatectomies (≥ 3 segments) and those receiving preoperative chemotherapy. The indices variation before and after chemotherapy were assessed for OS, DFS, and complete pathological response rates.Results
After exclusion criteria, 380 patients were selected for the study. No significant associations were found between inflammatory indices and OS or DFS. Lower preoperative PLR was associated with higher postoperative morbidity (p = 0.021) after major hepatectomies. Among patients receiving chemotherapy, a greater reduction in PLR was associated with a higher complete pathological response rate (p = 0.002).Conclusions
Although inflammatory indices were not predictive of survival outcomes, PLR was associated with postoperative morbidity and pathological response in specific subgroups; although these findings require validation.
Related
- Comparative efficacy of common adjuvant treatments after resection of colorectal liver metastases : A systematic review and network meta-analysis
- Individualised and Time-Dependent Prediction of Recurrence After Colorectal Cancer Liver Metastases Resection
- Peripheral immune-inflammatory markers associated with intracranial progression-free survival after Gamma Knife radiosurgery in patients with non-small cell lung cancer brain metastases: a retrospective cohort study.
- Radioembolization for Colorectal Liver Metastases: Indications and Outcomes
- Outcomes of Combined Hepatectomy and Intraoperative Ablation for Multiple Colorectal Liver Metastases: A Single-Center Retrospective Study
BibTeX
@article{cedro2026inflammatory,
title = {{Inflammatory Markers and Outcomes After Liver Resection for Colorectal Liver Metastases.}},
author = {Rider May Cedro and Gilton Marques Fonseca and Fabíola Trocoli Novaes and José Donizeti Meira Júnior and Vagner Birk Jeismann and Fabio Ferrari Makdissi and Jaime Arthur Pirolla Kruger and Fabricio Ferreira Coelho and Paulo Herman},
journal = {Cancer reports (Hoboken, N.J.)},
year = {2026},
month = nov,
doi = {10.1002/cnr2.70725},
url = {https://europepmc.org/article/MED/42974919},
note = {CC BY},
}
RIS
TY - JOUR
TI - Inflammatory Markers and Outcomes After Liver Resection for Colorectal Liver Metastases.
AU - Rider May Cedro
AU - Gilton Marques Fonseca
AU - Fabíola Trocoli Novaes
AU - José Donizeti Meira Júnior
AU - Vagner Birk Jeismann
AU - Fabio Ferrari Makdissi
AU - Jaime Arthur Pirolla Kruger
AU - Fabricio Ferreira Coelho
AU - Paulo Herman
PY - 2026
DA - 2026/11/01
JO - Cancer reports (Hoboken, N.J.)
DO - 10.1002/cnr2.70725
UR - https://europepmc.org/article/MED/42974919
AB - Background and objectives The liver is the main site of colorectal metastatic disease. This study evaluated the association of Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), and Monocyte-to-Lymphocyte Ratio (MLR) among patients with colorectal liver metastases (CRLM) undergoing liver resection.Methods A cohort of patients undergoing curative-intent liver resection for CRLM between 2009 and 2020 was evaluated. Association between inflammatory indices and overall survival (OS), disease-free survival (DFS), and postoperative morbidity and mortality were studied. Subgroup analyses included patients undergoing major hepatectomies (≥ 3 segments) and those receiving preoperative chemotherapy. The indices variation before and after chemotherapy were assessed for OS, DFS, and complete pathological response rates.Results After exclusion criteria, 380 patients were selected for the study. No significant associations were found between inflammatory indices and OS or DFS. Lower preoperative PLR was associated with higher postoperative morbidity (p = 0.021) after major hepatectomies. Among patients receiving chemotherapy, a greater reduction in PLR was associated with a higher complete pathological response rate (p = 0.002).Conclusions Although inflammatory indices were not predictive of survival outcomes, PLR was associated with postoperative morbidity and pathological response in specific subgroups; although these findings require validation.
SN - 2573-8348
ER -