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PreprintCC BY-NC-NDbioRxiv

Generation of an induced pluripotent stem cell line, LCSBi021-A, from a Parkinson's disease patient harboring the missense mutation c.213C>G (p.Ser71Arg) in the RAB32 gene

  • I. Boumpoureka1
  • V. Gorgogietas
  • E. Petkovski
  • R. Halder
  • F. Massart
  • NCER-PD Consortium
  • R. Krueger
  1. 1Luxembourg Institute of Health
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Abstract

Dermal fibroblasts were obtained from a 40-year-old male patient with Parkinson's disease (PD), harboring the c.213C>G (p.Ser71Arg) variant in the RAB32 gene. Induced pluripotent stem cells (iPSCs) were generated using the CytoTune-iPS 2.0 Sendai Reprogramming Kit (Thermo Fisher Scientific). The presence of the c.213C>G base exchange in exon 1 of RAB32 was confirmed by Next Generation Sequencing. The iPSCs are free of genomically integrated reprogramming genes, express pluripotency markers, display in vitro differentiation potential into all three germ layers and exhibit karyotypic integrity. Our iPSC line is available for research purposes to dissect molecular mechanisms of neurodegeneration in PD.

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Cite

BibTeXRIS
BibTeX
@misc{boumpoureka2026generation,
  title = {{Generation of an induced pluripotent stem cell line, LCSBi021-A, from a Parkinson's disease patient harboring the missense mutation c.213C>G (p.Ser71Arg) in the RAB32 gene}},
  author = {I. Boumpoureka and V. Gorgogietas and E. Petkovski and R. Halder and F. Massart and NCER-PD Consortium and R. Krueger},
  howpublished = {bioRxiv},
  year = {2026},
  month = oct,
  doi = {10.64898/2026.10.20.760406},
  url = {https://www.biorxiv.org/content/10.64898/2026.10.20.760406v1},
  note = {CC BY-NC-ND},
}
RIS
TY  - UNPB
TI  - Generation of an induced pluripotent stem cell line, LCSBi021-A, from a Parkinson's disease patient harboring the missense mutation c.213C>G (p.Ser71Arg) in the RAB32 gene
AU  - I. Boumpoureka
AU  - V. Gorgogietas
AU  - E. Petkovski
AU  - R. Halder
AU  - F. Massart
AU  - NCER-PD Consortium
AU  - R. Krueger
PY  - 2026
DA  - 2026/10/20
PB  - bioRxiv
DO  - 10.64898/2026.10.20.760406
UR  - https://www.biorxiv.org/content/10.64898/2026.10.20.760406v1
AB  - Dermal fibroblasts were obtained from a 40-year-old male patient with Parkinson's disease (PD), harboring the c.213C>G (p.Ser71Arg) variant in the RAB32 gene. Induced pluripotent stem cells (iPSCs) were generated using the CytoTune-iPS 2.0 Sendai Reprogramming Kit (Thermo Fisher Scientific). The presence of the c.213C>G base exchange in exon 1 of RAB32 was confirmed by Next Generation Sequencing. The iPSCs are free of genomically integrated reprogramming genes, express pluripotency markers, display in vitro differentiation potential into all three germ layers and exhibit karyotypic integrity. Our iPSC line is available for research purposes to dissect molecular mechanisms of neurodegeneration in PD.
ER  -