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Peer-reviewedCC BY 4.0International Journal of Molecular Sciences

Fibrin Clot Properties in Aneurysmal Coronary Artery Disease: CARE-ANEURYSM Study

  • Jakub Chmiel1,2,3,4
  • Magdalena Kopytek2,3,5
  • Maciej Dąbrowski6
  • Sylwia Iwańczyk7
  • Karol Musiał1
  • Patrycja Woźniak7
  • Julianna Chmiel1
  • Łukasz Partyka8
  • Michał Ząbczyk2,3,5
  • Joanna Natorska2,3,5
  • Piotr Musiałek1,3
8 affiliations
  1. 1Department of Cardiac and Vascular Diseases, Institute of Cardiology, Jagiellonian University Medical College, 31-202 Krakow, Poland
  2. 2Krakow Center for Medical Research and Technologies, St. John Paul II Hospital, 31-202 Krakow, Poland
  3. 3St. John Paul II Hospital, 31-202 Krakow, Poland
  4. 4Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College, 31-530 Krakow, Poland
  5. 5Department of Thromboembolic Disorders, Institute of Cardiology, Jagiellonian University Medical College, 31-202 Krakow, Poland
  6. 6Department of Interventional Cardiology and Angiology, National Institute of Cardiology, 04-628 Warsaw, Poland
  7. 71st Department of Cardiology, Poznan University of Medical Sciences, 61-848 Poznan, Poland
  8. 8KCRI Angiographic Core Laboratory, 30-347 Krakow, Poland
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Abstract

Coronary artery ectasias and aneurysms (CAEAs) are present in up to 5% of patients undergoing coronary angiography. Recent studies indicated an independent association between CAEA and the risk of myocardial infarction but the underlying mechanisms have not yet been elucidated. We evaluated the relationship between CAEA and fibrin clot properties in 60 consecutive CAEA subjects and 60 clinically/angiographically matched controls enrolled across three tertiary centers. Fibrin clot permeability coefficient (Ks), clot lysis time (CLT), and levels of 3-nitrotyrosine, an oxidative stress marker, were assessed. Among patients with CAEA, 52 (86.7%) were male, the median age was 66.0 (59.5–74.1) years, and 30 (50.0%) had concomitant coronary artery disease. Compared with controls, CAEA subjects had 14% lower Ks (p = 0.036), 25% longer CLT (p = 0.001), and 21% higher 3-nitrotyrosine levels (p = 0.002). Multivariable regression analysis showed an association of CAEA with lower Ks, longer CLT, and higher 3-nitrotyrosine levels (all p < 0.05). In CAEA patients, 3-nitrotyrosine levels correlated with Ks (r = −0.31, p = 0.016) and CLT (r = 0.27, p = 0.037). With increasing CAEA peak-to-reference diameter ratio, Ks decreased (p-trend = 0.017), and 3-nitrotyrosine levels increased (p-trend = 0.002). In conclusion, we found that CAEA is independently associated with unfavorably altered fibrin clot properties, reflected by denser clot structure and reduced susceptibility to fibrinolysis. Our findings suggest that oxidative stress may contribute to unfavorable modification of fibrin clot properties in CAEA. With an increase in CAEA size, there is an increase in oxidative stress and worsening of the fibrin clot phenotype (CARE-ANEURYSM, NCT05183373).

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Cite

BibTeXRIS
BibTeX
@article{chmiel2026fibrin,
  title = {{Fibrin Clot Properties in Aneurysmal Coronary Artery Disease: CARE-ANEURYSM Study}},
  author = {Jakub Chmiel and Magdalena Kopytek and Maciej Dąbrowski and Sylwia Iwańczyk and Karol Musiał and Patrycja Woźniak and Julianna Chmiel and Łukasz Partyka and Michał Ząbczyk and Joanna Natorska and Piotr Musiałek},
  journal = {International Journal of Molecular Sciences},
  year = {2026},
  month = oct,
  doi = {10.3390/ijms27209059},
  url = {https://www.mdpi.com/1422-0067/27/20/9059},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Fibrin Clot Properties in Aneurysmal Coronary Artery Disease: CARE-ANEURYSM Study
AU  - Jakub Chmiel
AU  - Magdalena Kopytek
AU  - Maciej Dąbrowski
AU  - Sylwia Iwańczyk
AU  - Karol Musiał
AU  - Patrycja Woźniak
AU  - Julianna Chmiel
AU  - Łukasz Partyka
AU  - Michał Ząbczyk
AU  - Joanna Natorska
AU  - Piotr Musiałek
PY  - 2026
DA  - 2026/10/01
JO  - International Journal of Molecular Sciences
DO  - 10.3390/ijms27209059
UR  - https://www.mdpi.com/1422-0067/27/20/9059
AB  - Coronary artery ectasias and aneurysms (CAEAs) are present in up to 5% of patients undergoing coronary angiography. Recent studies indicated an independent association between CAEA and the risk of myocardial infarction but the underlying mechanisms have not yet been elucidated. We evaluated the relationship between CAEA and fibrin clot properties in 60 consecutive CAEA subjects and 60 clinically/angiographically matched controls enrolled across three tertiary centers. Fibrin clot permeability coefficient (Ks), clot lysis time (CLT), and levels of 3-nitrotyrosine, an oxidative stress marker, were assessed. Among patients with CAEA, 52 (86.7%) were male, the median age was 66.0 (59.5–74.1) years, and 30 (50.0%) had concomitant coronary artery disease. Compared with controls, CAEA subjects had 14% lower Ks (p = 0.036), 25% longer CLT (p = 0.001), and 21% higher 3-nitrotyrosine levels (p = 0.002). Multivariable regression analysis showed an association of CAEA with lower Ks, longer CLT, and higher 3-nitrotyrosine levels (all p < 0.05). In CAEA patients, 3-nitrotyrosine levels correlated with Ks (r = −0.31, p = 0.016) and CLT (r = 0.27, p = 0.037). With increasing CAEA peak-to-reference diameter ratio, Ks decreased (p-trend = 0.017), and 3-nitrotyrosine levels increased (p-trend = 0.002). In conclusion, we found that CAEA is independently associated with unfavorably altered fibrin clot properties, reflected by denser clot structure and reduced susceptibility to fibrinolysis. Our findings suggest that oxidative stress may contribute to unfavorable modification of fibrin clot properties in CAEA. With an increase in CAEA size, there is an increase in oxidative stress and worsening of the fibrin clot phenotype (CARE-ANEURYSM, NCT05183373).
SN  - 1422-0067
ER  -