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Peer-reviewedCC BY-NC-ND 4.0ACS Omega

Microbubble-Assisted Bioresorbable Biphasic Scaffolds Reinforced with TiO2 Nanosheets for Oral and Maxillofacial Bone Repair: In Vitro Evaluation

  • Tanchanok Parivatphun1
  • Matthana Khangkhamano1
  • Jirut Meesane1
  • Rungrote Kokoo2
  • Sittichat Chukaew1
  • Lerrat Chuaibamrung1
  1. 1Prince of Songkla University , , , ,
  2. 2Faculty of Engineering, King Mongkut’s University of Technology , , ,
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Abstract

This study presents the development of bioresorbable biphasic scaffolds incorporating titanium dioxide (TiO2) nanostructures, specifically nanoparticles (TNPs) and nanosheets (TNSs), into a poly(vinyl alcohol) (PVA) and silk fibroin (SF) polymeric matrix using a bubbling technique followed by freeze-drying. Both TNPs and TNSs were synthesized via a hydrothermal method. The resulting scaffolds featured two distinct layers: a porous sponge-like structure and a dense film, designed to mimic the architecture of natural bone and soft tissue interfaces in oral and maxillofacial regions. Structural characterization confirmed the successful integration of TiO2 nanostructures within the scaffold matrix. X-ray diffraction showed that both TNPs and TNSs exhibited a pure anatase phase. Compared to TNPs, the nanosheet form offered significantly improved molecular mobility and dispersion within the matrix. Additionally, TNSs-incorporated scaffolds exhibited favorable porosity, compressive strength, swelling behavior, and degradation rate. In vitro studies demonstrated enhanced proliferation of both osteoblasts and fibroblasts, particularly in the TNSs scaffolds. The anatase-phase TiO2 contributed to improved cell-material interactions and scaffold performance without significant cytotoxicity. These findings suggest that TNSs-based scaffolds hold strong potential as functional biomaterials for oral and maxillofacial tissue repair, including alveolar cleft and mandibular ridge reconstruction.

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Cite

BibTeXRIS
BibTeX
@article{parivatphun2026microbubbleassisted,
  title = {{Microbubble-Assisted Bioresorbable Biphasic Scaffolds Reinforced with TiO2 Nanosheets for Oral and Maxillofacial Bone Repair: In Vitro Evaluation}},
  author = {Tanchanok Parivatphun and Matthana Khangkhamano and Jirut Meesane and Rungrote Kokoo and Sittichat Chukaew and Lerrat Chuaibamrung},
  journal = {ACS Omega},
  year = {2026},
  month = nov,
  doi = {10.1021/acsomega.6c04873},
  url = {https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c04873/5466022/Microbubble-Assisted-Bioresorbable-Biphasic},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Microbubble-Assisted Bioresorbable Biphasic Scaffolds Reinforced with TiO2 Nanosheets for Oral and Maxillofacial Bone Repair: In Vitro Evaluation
AU  - Tanchanok Parivatphun
AU  - Matthana Khangkhamano
AU  - Jirut Meesane
AU  - Rungrote Kokoo
AU  - Sittichat Chukaew
AU  - Lerrat Chuaibamrung
PY  - 2026
DA  - 2026/11/06
JO  - ACS Omega
DO  - 10.1021/acsomega.6c04873
UR  - https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c04873/5466022/Microbubble-Assisted-Bioresorbable-Biphasic
AB  - This study presents the development of bioresorbable biphasic scaffolds incorporating titanium dioxide (TiO2) nanostructures, specifically nanoparticles (TNPs) and nanosheets (TNSs), into a poly(vinyl alcohol) (PVA) and silk fibroin (SF) polymeric matrix using a bubbling technique followed by freeze-drying. Both TNPs and TNSs were synthesized via a hydrothermal method. The resulting scaffolds featured two distinct layers: a porous sponge-like structure and a dense film, designed to mimic the architecture of natural bone and soft tissue interfaces in oral and maxillofacial regions. Structural characterization confirmed the successful integration of TiO2 nanostructures within the scaffold matrix. X-ray diffraction showed that both TNPs and TNSs exhibited a pure anatase phase. Compared to TNPs, the nanosheet form offered significantly improved molecular mobility and dispersion within the matrix. Additionally, TNSs-incorporated scaffolds exhibited favorable porosity, compressive strength, swelling behavior, and degradation rate. In vitro studies demonstrated enhanced proliferation of both osteoblasts and fibroblasts, particularly in the TNSs scaffolds. The anatase-phase TiO2 contributed to improved cell-material interactions and scaffold performance without significant cytotoxicity. These findings suggest that TNSs-based scaffolds hold strong potential as functional biomaterials for oral and maxillofacial tissue repair, including alveolar cleft and mandibular ridge reconstruction.
SN  - 2470-1343
ER  -