Skip to content
DraconiticResearch
Search Sources API
201,818 studies31 sourcesUpdated 23 min ago
Peer-reviewedCC BYScientific Reports

Novel polysaccharides from Metarhizium pinghaense modulate bovine satellite cell fate for cultured meat production

  • J. H. Park1
  • J. W. Jang2
  • S. W. Jang1
  • Y. R. Kim3
  • J. H. Han1
  • G. R. Na1
  • Ikju. Park4
  • T. Y. Shin2
  • H. W. Choi1
4 affiliations
  1. 1Department of Agricultural Convergence Technology, Jeonbuk National University
  2. 2Department of Agricultural Biology, College of Agriculture & Life Sciences, Jeonbuk National University
  3. 3Department of Animal Science, Jeonbuk National University
  4. 4Department of Entomology, University of California
Read full textPDFDOICite

Abstract

The finite proliferative lifespan and progressive loss of stemness in muscle stem cells present a significant bottleneck for the industrial-scale manufacturing of cultured meat. To overcome this limitation, we evaluated a microbial polysaccharide from Metarhizium pinghaense 15R (MP15R) for its capacity to augment bovine satellite cells (BSCs) functionality. Our in vitro findings demonstrate that MP15R treatment enhanced BSCs proliferation and migration while sustaining elevated expression of the canonical stem cell marker PAX7 throughout prolonged passaging. Moreover, upon induction, MP15R robustly promoted terminal myogenic differentiation, evidenced by the upregulation of key markers such as MYOG and MYHC and an increased myotube fusion index. Collectively, these results establish the MP15R polysaccharide as a sustainable, cost-effective bioactive agent with a bifunctional capacity to improve both the expansion and differentiation phases essential for cultured meat bioprocessing.

Related

  1. Natural polysaccharides as modulators of mitochondrial homeostasis: structural determinants, pharmacological mechanisms, and translational challenges
    Xinfang Du, Jingwen Zhang, Wenjing Li +1
    Frontiers in PharmacologyPeer-reviewedCC BY 4.0Full textMolecular biology & gene regulationCrossrefEurope PMCPMC
  2. Extraction, Structure–Activity Relationships, and Modification of Plant-Derived Polysaccharides: An Integrated Framework for Evidence-Based Method Selection and Bioactivity Optimization—A Review
    Yuting He, Yu Xin, Xiwu Zhang +8
    International journal of molecular sciencesPeer-reviewedCC BYFull textGeneral biochemistryEurope PMCCrossref
  3. Pectic Polysaccharides and Glucans in Macrophage Redox-Immune Crosstalk: Structural Determinants, Receptor Signaling, and Evidence Boundaries
    Henan Sun, Hao Yu, Huiqiang Yu +4
    BiomoleculesPeer-reviewedCC BY 4.0General biochemistryCrossref
  4. Lipid Nanoparticle Surface Engineering with Heparosan Polysaccharides Enhances mRNA Efficacy via Reduced Endosomal Retention.
    Yuxin He, Lin Wang, Abigael P Williams +13
    ACS nanoPeer-reviewedCC BYFull textMolecular biology & gene regulationEurope PMC
  5. The Gut Microbiota as a Mediator of the Metabolic Benefits of Fungi and Their Polysaccharides: A Review of Evidence Addressing Causality
    Stevan Samardžić, Dragana D. Božić, Milica Drobac +4
    NutrientsPeer-reviewedCC BYFull textMolecular biology & gene regulationEurope PMCCrossref

Cite

BibTeXRIS
BibTeX
@article{park2026novel,
  title = {{Novel polysaccharides from Metarhizium pinghaense modulate bovine satellite cell fate for cultured meat production}},
  author = {J. H. Park and J. W. Jang and S. W. Jang and Y. R. Kim and J. H. Han and G. R. Na and Ikju. Park and T. Y. Shin and H. W. Choi},
  journal = {Scientific Reports},
  year = {2026},
  month = jul,
  doi = {10.1038/s41598-026-61953-1},
  url = {https://doi.org/10.1038/s41598-026-61953-1},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Novel polysaccharides from Metarhizium pinghaense modulate bovine satellite cell fate for cultured meat production
AU  - J. H. Park
AU  - J. W. Jang
AU  - S. W. Jang
AU  - Y. R. Kim
AU  - J. H. Han
AU  - G. R. Na
AU  - Ikju. Park
AU  - T. Y. Shin
AU  - H. W. Choi
PY  - 2026
DA  - 2026/07/01
JO  - Scientific Reports
DO  - 10.1038/s41598-026-61953-1
UR  - https://doi.org/10.1038/s41598-026-61953-1
AB  - The finite proliferative lifespan and progressive loss of stemness in muscle stem cells present a significant bottleneck for the industrial-scale manufacturing of cultured meat. To overcome this limitation, we evaluated a microbial polysaccharide from Metarhizium pinghaense 15R (MP15R) for its capacity to augment bovine satellite cells (BSCs) functionality. Our in vitro findings demonstrate that MP15R treatment enhanced BSCs proliferation and migration while sustaining elevated expression of the canonical stem cell marker PAX7 throughout prolonged passaging. Moreover, upon induction, MP15R robustly promoted terminal myogenic differentiation, evidenced by the upregulation of key markers such as MYOG and MYHC and an increased myotube fusion index. Collectively, these results establish the MP15R polysaccharide as a sustainable, cost-effective bioactive agent with a bifunctional capacity to improve both the expansion and differentiation phases essential for cultured meat bioprocessing.
SN  - 2045-2322
ER  -