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Peer-reviewedCC BYFrontiers in medicine

Pulmonary hypertension in a patient with HHV-8-negative multicentric castleman disease and epstein-barr virus co-infection: a case report.

  • Xi Yan1
  • Lipin Xie2
  • Hongrui Li1
  • Jiao Tang3
  • Maoyun Wang1
  • Lan Wang1
  1. 1Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
  2. 2Department of Hematology, West China Hospital, Sichuan University, Chengdu, China.
  3. 3Department of Respiratory and Critical Care Medicine, The People's Hospital of Liuyang City, Liuyang, China.
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Abstract

Pulmonary hypertension (PH) seems to be a rare but severe complication of Castleman disease (CD), especially the multicentric type (MCD). We report a case of recurrent fever, anemia and progressive dyspnea. She was finally diagnosed with pre-capillary PH in the setting of MCD and Epstein-Barr virus (EBV) co-infection after right heart catheterization and lymph node biopsy. After receiving siltuximab, an anti-interleukin-6 monoclonal antibody along with diuretic agent, the symptoms were relieved. However, the patient died 8 months after diagnosis due to a pulmonary hypertensive crisis secondary to clinically diagnosed bacterial pneumonia presenting with severe dyspnea, refractory hypoxemia, and acute right ventricular failure. This rare case improves recognition of this infrequent etiology of PH.

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Cite

BibTeXRIS
BibTeX
@article{yan2026pulmonary,
  title = {{Pulmonary hypertension in a patient with HHV-8-negative multicentric castleman disease and epstein-barr virus co-infection: a case report.}},
  author = {Xi Yan and Lipin Xie and Hongrui Li and Jiao Tang and Maoyun Wang and Lan Wang},
  journal = {Frontiers in medicine},
  year = {2026},
  month = oct,
  doi = {10.3389/fmed.2026.1951176},
  url = {https://europepmc.org/article/MED/42953637},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Pulmonary hypertension in a patient with HHV-8-negative multicentric castleman disease and epstein-barr virus co-infection: a case report.
AU  - Xi Yan
AU  - Lipin Xie
AU  - Hongrui Li
AU  - Jiao Tang
AU  - Maoyun Wang
AU  - Lan Wang
PY  - 2026
DA  - 2026/10/14
JO  - Frontiers in medicine
DO  - 10.3389/fmed.2026.1951176
UR  - https://europepmc.org/article/MED/42953637
AB  - Pulmonary hypertension (PH) seems to be a rare but severe complication of Castleman disease (CD), especially the multicentric type (MCD). We report a case of recurrent fever, anemia and progressive dyspnea. She was finally diagnosed with pre-capillary PH in the setting of MCD and Epstein-Barr virus (EBV) co-infection after right heart catheterization and lymph node biopsy. After receiving siltuximab, an anti-interleukin-6 monoclonal antibody along with diuretic agent, the symptoms were relieved. However, the patient died 8 months after diagnosis due to a pulmonary hypertensive crisis secondary to clinically diagnosed bacterial pneumonia presenting with severe dyspnea, refractory hypoxemia, and acute right ventricular failure. This rare case improves recognition of this infrequent etiology of PH.
SN  - 2296-858X
ER  -