Burden and determinants of hyperuricemia among adults living with HIV at Lira Regional Referral Hospital in Uganda : a cross-sectional study
- 1Department of Internal Medicine, Faculty of Clinical Medicine and Dentistry, Kampala International University, Kampala, Uganda
- 2Department of Obstetrics and Gynecology, faculty of clinical Medicine and Dentistry, Kampala International University, Kampala, Uganda
- 3Department of Microbiology and Immunology, Faculty of Biomedical Sciences, Kampala International University, Kampala, Uganda
Abstract
Background: Hyperuricemia is an emerging metabolic complication among people living with HIV in the era of antiretroviral therapy (ART), yet evidence from sub-Saharan Africa remains limited.
Methods: A cross-sectional study was conducted at the LRRH Infectious Disease Centre between December 2024 and March 2025. A total of 385 adults living with HIV were selected using systematic sampling. Data were collected on sociodemographic, clinical, behavioral, and biochemical variables through interviews, physical examination, and laboratory testing. Serum uric acid, lipid profile, creatinine, and blood pressure were measured. Hyperuricemia was defined as serum uric acid > 7.0 mg/dL in males and > 6.0 mg/dL in females. Logistic regression was used to identify associated factors. Cardiovascular risk was assessed using the Framingham Risk Score (FRS).
Results: The prevalence of hyperuricemia was 21.8%. Significant predictors included comorbidities (AOR=2.16, 95% CI 1.18–3.97), elevated total cholesterol (AOR=1.79, 95% CI 1.02–3.14), overweight/obesity (AOR=4.92, 95% CI 2.73–8.84), elevated systolic blood pressure (AOR=2.12, 95% CI 1.18–3.82), and cigarette smoking (AOR=4.89, 95% CI 2.59–9.23). Hyperuricemia was significantly associated with high cardiovascular risk according to FRS classification (p<0.001).
Conclusion: Hyperuricemia is prevalent among adults living with HIV at LRRH and is strongly associated with modifiable cardiometabolic and behavioral risk factors. These findings support routine screening and integrated cardiovascular-metabolic management within HIV care services.
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BibTeX
@article{nor2026burden,
title = {{Burden and determinants of hyperuricemia among adults living with HIV at Lira Regional Referral Hospital in Uganda : a cross-sectional study}},
author = {Fatima Ibrahim Nor and Mohamed Jayte and Agwu Ezera and Mohamed Elmalik Musa and Mutaz Ali and Nixson Oyanga and Abdullahi Hussein Ahmed and Abdifatah Hersi Karshe and Hassan Omar Ali and Theoneste Hakizimana and Abishir Mohamud Hirsi},
journal = {AIDS Research and Therapy},
year = {2026},
month = jul,
doi = {10.1186/s12981-026-00923-z},
url = {https://doi.org/10.1186/s12981-026-00923-z},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Burden and determinants of hyperuricemia among adults living with HIV at Lira Regional Referral Hospital in Uganda : a cross-sectional study
AU - Fatima Ibrahim Nor
AU - Mohamed Jayte
AU - Agwu Ezera
AU - Mohamed Elmalik Musa
AU - Mutaz Ali
AU - Nixson Oyanga
AU - Abdullahi Hussein Ahmed
AU - Abdifatah Hersi Karshe
AU - Hassan Omar Ali
AU - Theoneste Hakizimana
AU - Abishir Mohamud Hirsi
PY - 2026
DA - 2026/07/18
JO - AIDS Research and Therapy
DO - 10.1186/s12981-026-00923-z
UR - https://doi.org/10.1186/s12981-026-00923-z
AB - Background: Hyperuricemia is an emerging metabolic complication among people living with HIV in the era of antiretroviral therapy (ART), yet evidence from sub-Saharan Africa remains limited. Methods: A cross-sectional study was conducted at the LRRH Infectious Disease Centre between December 2024 and March 2025. A total of 385 adults living with HIV were selected using systematic sampling. Data were collected on sociodemographic, clinical, behavioral, and biochemical variables through interviews, physical examination, and laboratory testing. Serum uric acid, lipid profile, creatinine, and blood pressure were measured. Hyperuricemia was defined as serum uric acid > 7.0 mg/dL in males and > 6.0 mg/dL in females. Logistic regression was used to identify associated factors. Cardiovascular risk was assessed using the Framingham Risk Score (FRS). Results: The prevalence of hyperuricemia was 21.8%. Significant predictors included comorbidities (AOR=2.16, 95% CI 1.18–3.97), elevated total cholesterol (AOR=1.79, 95% CI 1.02–3.14), overweight/obesity (AOR=4.92, 95% CI 2.73–8.84), elevated systolic blood pressure (AOR=2.12, 95% CI 1.18–3.82), and cigarette smoking (AOR=4.89, 95% CI 2.59–9.23). Hyperuricemia was significantly associated with high cardiovascular risk according to FRS classification (p<0.001). Conclusion: Hyperuricemia is prevalent among adults living with HIV at LRRH and is strongly associated with modifiable cardiometabolic and behavioral risk factors. These findings support routine screening and integrated cardiovascular-metabolic management within HIV care services.
SN - 1742-6405
ER -