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Peer-reviewedCC BY 4.0The Journal of Laryngology and Otology

Prognostic value of gross tumour volume in laryngeal cancer: a systematic review and meta-analysis

  • Shahid Iqbal1
  • Saad Illahi2
  • Rumail Zaheer3
  • Ashir Iqbal4
  • Ely Cheikh Boussaty1
  • Charles S. Coffey1
4 affiliations
  1. 1Department of Otolaryngology - Head & Neck Surgery, University of California San Diego, USA
  2. 2Calderdale and Huddersfield NHS Foundation Trust, UK
  3. 3Macquarie University Hospital, Australia
  4. 4Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, UK
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Abstract

Objectives: Gross tumour volume has been proposed as a complementary prognostic marker in laryngeal squamous cell carcinoma. This systematic review and meta-analysis evaluates the prognostic value of pre-treatment gross tumour volume.

Methods: MEDLINE, Embase and Scopus were systematically searched according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies reporting pre-treatment gross tumour volume and survival outcomes in laryngeal cancer were included. The primary outcome was overall survival, and the secondary outcome was disease-free survival. Hazard ratios were pooled using random-effects meta-analysis. Risk of bias was assessed using the Quality in Prognosis Studies tool, and certainty of evidence using the Grading of Recommendations Assessment, Development and Evaluation approach.

Results: Eight retrospective studies including 1351 patients were included. Increasing gross tumour volume was significantly associated with worse overall survival (pooled hazard ratio per 1 cm3 increase: 1.03; 95 per cent confidence interval: 1.02–1.05), with a similar association observed for disease-free survival. Overall risk of bias was moderate.

Conclusions: Higher gross tumour volume is independently associated with poorer survival in laryngeal cancer and may provide prognostic information beyond tumour-node-metastasis staging.

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Cite

BibTeXRIS
BibTeX
@article{iqbal2026prognostic,
  title = {{Prognostic value of gross tumour volume in laryngeal cancer: a systematic review and meta-analysis}},
  author = {Shahid Iqbal and Saad Illahi and Rumail Zaheer and Ashir Iqbal and Ely Cheikh Boussaty and Charles S. Coffey},
  journal = {The Journal of Laryngology and Otology},
  year = {2026},
  month = nov,
  doi = {10.1017/s0022215126105313},
  url = {https://doi.org/10.1017/s0022215126105313},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Prognostic value of gross tumour volume in laryngeal cancer: a systematic review and meta-analysis
AU  - Shahid Iqbal
AU  - Saad Illahi
AU  - Rumail Zaheer
AU  - Ashir Iqbal
AU  - Ely Cheikh Boussaty
AU  - Charles S. Coffey
PY  - 2026
DA  - 2026/11/06
JO  - The Journal of Laryngology and Otology
DO  - 10.1017/s0022215126105313
UR  - https://doi.org/10.1017/s0022215126105313
AB  - Objectives: Gross tumour volume has been proposed as a complementary prognostic marker in laryngeal squamous cell carcinoma. This systematic review and meta-analysis evaluates the prognostic value of pre-treatment gross tumour volume.  Methods: MEDLINE, Embase and Scopus were systematically searched according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies reporting pre-treatment gross tumour volume and survival outcomes in laryngeal cancer were included. The primary outcome was overall survival, and the secondary outcome was disease-free survival. Hazard ratios were pooled using random-effects meta-analysis. Risk of bias was assessed using the Quality in Prognosis Studies tool, and certainty of evidence using the Grading of Recommendations Assessment, Development and Evaluation approach.  Results: Eight retrospective studies including 1351 patients were included. Increasing gross tumour volume was significantly associated with worse overall survival (pooled hazard ratio per 1 cm3 increase: 1.03; 95 per cent confidence interval: 1.02–1.05), with a similar association observed for disease-free survival. Overall risk of bias was moderate.  Conclusions: Higher gross tumour volume is independently associated with poorer survival in laryngeal cancer and may provide prognostic information beyond tumour-node-metastasis staging.
SN  - 0022-2151
SN  - 1748-5460
ER  -