Peer-reviewedCC BY 4.0Journal of Interventional Cardiac Electrophysiology
A surgical epicardial approach to mapping and ablation in large animal models
5 affiliations
- 1Division of Cardiology, Department of Medicine, College of Medicine, University of Illinois Chicago, Chicago, IL USA
- 2Jesse Brown VA Medical Center, Chicago, IL USA
- 3Department of Physiology and Biophysics and the Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, Chicago, IL USA
- 4Texas Heart Institute and Baylor College of Medicine, Houston, TX USA
- 5Division of Cardiology, Department of Medicine, University of Illinois Chicago, 840 S. Wood St., 920S (MC 715), Chicago, IL 60612 USA
Abstract
Large animal surgeries are the standard for validating pre-clinical electrophysiology studies, and serve as an important step for the rationale underlying clinical trials. Although electrophysiologists receive extensive training in catheter-based approaches, few medical centers have the capability to perform experimental animal surgeries in large animals. Here, we present a step-by-step guide to performing an epicardial approach to pacing and sensing in a large animal sheep model, with the goal of enabling a wide variety of pacing and ablation options.
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BibTeX
@article{lizama2026surgical,
title = {{A surgical epicardial approach to mapping and ablation in large animal models}},
author = {Ken S. Lizama and Abdelmotogaly Elgalad and Tirth A. Patel and Matthews John and Mehdi Razavi and Mark D. McCauley},
journal = {Journal of Interventional Cardiac Electrophysiology},
year = {2026},
month = may,
doi = {10.1007/s10840-026-02353-3},
url = {https://doi.org/10.1007/s10840-026-02353-3},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - A surgical epicardial approach to mapping and ablation in large animal models
AU - Ken S. Lizama
AU - Abdelmotogaly Elgalad
AU - Tirth A. Patel
AU - Matthews John
AU - Mehdi Razavi
AU - Mark D. McCauley
PY - 2026
DA - 2026/05/21
JO - Journal of Interventional Cardiac Electrophysiology
DO - 10.1007/s10840-026-02353-3
UR - https://doi.org/10.1007/s10840-026-02353-3
AB - Large animal surgeries are the standard for validating pre-clinical electrophysiology studies, and serve as an important step for the rationale underlying clinical trials. Although electrophysiologists receive extensive training in catheter-based approaches, few medical centers have the capability to perform experimental animal surgeries in large animals. Here, we present a step-by-step guide to performing an epicardial approach to pacing and sensing in a large animal sheep model, with the goal of enabling a wide variety of pacing and ablation options.
SN - 1383-875X
SN - 1572-8595
ER -