meso -Tetra(bifluorenyl)porphyrins functionalized with Ru(dppe) 2 Cl alkynyl complexes: remarkable organometallic photosensitizers with strong nonlinear absorption properties
Abstract
Two-photon absorption (2PA) has emerged as a powerful strategy in photodynamic therapy (PDT), enabling deeper tissue penetration and spatially controlled photoactivation within the near-infrared (NIR) therapeutic window. Herein, we report the synthesis of a series of four porphyrin derivatives based on a meso-tetrafluorenylporphyrin core functionalized with four trans-chlorobis(dppe)ruthenium alkynyl units (dppe = 1,2-bis(diphenyl-phosphino)ethane) at the periphery. Their UV-vis (linear) and third-order nonlinear absorption properties were systematically investigated. In these multipolar assemblies, the incorporation of organoruthenium endgroups markedly enhances the two-photon absorption (2PA) cross-sections while efficiently quenching any light emission. As a result, remarkable photothermal molecules with strong nonlinear absorption in the near-IR range and also oxygen-photosensitizing properties are obtained. Despite their pronounced hydrophobicity, these organometallic photosensitizers can be effectively internalized in cellulo through encapsulation within polymeric nanoparticles (NPs) which allows anticancerous phototherapy with MCF-7 cell lines. Finally, the remarkable third-order nonlinear optical (NLO) properties of these outstanding two-photon absorbers, as well as their potential applications in various fields are briefly discussed.
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BibTeX
@article{shi2026meso,
title = {{meso -Tetra(bifluorenyl)porphyrins functionalized with Ru(dppe) 2 Cl alkynyl complexes: remarkable organometallic photosensitizers with strong nonlinear absorption properties}},
author = {Limiao Shi and Viktoriia Gorbunova and Leszek M Mazur and Nina Tarnowicz-Staniak and Marek Samoć and Katarzyna Matczyszyn and Christophe Nguyen and Magali Gary-Bobo and Sandrine Cammas-Marion and Olivier Mongin and Frédéric Paul and Christine Odile Paul-Roth},
journal = {Journal of Materials Chemistry C},
year = {2026},
month = sep,
doi = {10.1039/d6tc02515c},
url = {https://hal.science/hal-05781136v1},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - meso -Tetra(bifluorenyl)porphyrins functionalized with Ru(dppe) 2 Cl alkynyl complexes: remarkable organometallic photosensitizers with strong nonlinear absorption properties
AU - Limiao Shi
AU - Viktoriia Gorbunova
AU - Leszek M Mazur
AU - Nina Tarnowicz-Staniak
AU - Marek Samoć
AU - Katarzyna Matczyszyn
AU - Christophe Nguyen
AU - Magali Gary-Bobo
AU - Sandrine Cammas-Marion
AU - Olivier Mongin
AU - Frédéric Paul
AU - Christine Odile Paul-Roth
PY - 2026
DA - 2026/09/14
JO - Journal of Materials Chemistry C
DO - 10.1039/d6tc02515c
UR - https://hal.science/hal-05781136v1
AB - Two-photon absorption (2PA) has emerged as a powerful strategy in photodynamic therapy (PDT), enabling deeper tissue penetration and spatially controlled photoactivation within the near-infrared (NIR) therapeutic window. Herein, we report the synthesis of a series of four porphyrin derivatives based on a meso-tetrafluorenylporphyrin core functionalized with four trans-chlorobis(dppe)ruthenium alkynyl units (dppe = 1,2-bis(diphenyl-phosphino)ethane) at the periphery. Their UV-vis (linear) and third-order nonlinear absorption properties were systematically investigated. In these multipolar assemblies, the incorporation of organoruthenium endgroups markedly enhances the two-photon absorption (2PA) cross-sections while efficiently quenching any light emission. As a result, remarkable photothermal molecules with strong nonlinear absorption in the near-IR range and also oxygen-photosensitizing properties are obtained. Despite their pronounced hydrophobicity, these organometallic photosensitizers can be effectively internalized in cellulo through encapsulation within polymeric nanoparticles (NPs) which allows anticancerous phototherapy with MCF-7 cell lines. Finally, the remarkable third-order nonlinear optical (NLO) properties of these outstanding two-photon absorbers, as well as their potential applications in various fields are briefly discussed.
SN - 2050-7526
SN - 2050-7534
ER -