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Peer-reviewedCC BYCardiology research

Association Between Changes in Paravalvular Leakage After Transcatheter Aortic Valve Implantation and Serum Lactate Dehydrogenase.

  • Akihiro Ikuta1
  • Gakuto Bando1
  • Satoki Oka1
  • Shunsuke Matsushita1
  • Naoya Inoue1
  • Shingo Hirao2
  • Mitsuru Abe1
  • Kazushige Kadota1
  • Tatsuhiko Komiya2
  • Yasushi Fuku1
  1. 1Department of Cardiovascular Medicine, Kurashiki Central Hospital, Kurashiki, Japan.
  2. 2Department of Cardiovascular Surgery, Kurashiki Central Hospital, Kurashiki, Japan.
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Abstract

Background

The association between changes in paravalvular leakage (PVL) and serum lactate dehydrogenase (LDH) levels in patients undergoing transcatheter aortic valve implantation (TAVI) is unexplored. We aimed to investigate the short-term changes in PVL after TAVI and their association with LDH elevation.Methods

A total of 550 consecutive patients underwent TAVI from 2020 to 2024. Of these, 313 receiving SAPIEN 3 (S3) or SAPIEN 3 Ultra RESILIA (S3UR) valves were included in this study. Patients were categorized into two groups based on whether their PVL severity worsened by at least one grade from immediately after the procedure to hospital discharge.Results

PVL deterioration was observed in 16.3% of patients. The incidence of moderate or greater LDH elevation was significantly higher in the PVL deterioration group than in the non-PVL deterioration group at 7 days (17.6% vs. 8.4%; P = 0.04) and 1 month (29.4% vs. 8.8%; P < 0.01) after the procedure. The area under the receiver operating characteristic (ROC) curve for predicting PVL deterioration using the sizing index (SI) was 0.84, with an optimal cut-off value of 96.5% (odds ratio (OR): 13.6; 95% confidence interval (CI): 6.55-31.1; P < 0.01). Multivariable analysis showed that an aortic valve calcium score ≥ 1,435, use of the S3UR valve, and an SI < 96.5 were independently associated with PVL deterioration.Conclusion

Early PVL deterioration after TAVI with a balloon-expandable valve may be associated with LDH elevation. These findings highlight the importance of selecting a prosthetic valve with an appropriate sizing ratio to minimize PVL deterioration after TAVI.

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Cite

BibTeXRIS
BibTeX
@article{ikuta2026association,
  title = {{Association Between Changes in Paravalvular Leakage After Transcatheter Aortic Valve Implantation and Serum Lactate Dehydrogenase.}},
  author = {Akihiro Ikuta and Gakuto Bando and Satoki Oka and Shunsuke Matsushita and Naoya Inoue and Shingo Hirao and Mitsuru Abe and Kazushige Kadota and Tatsuhiko Komiya and Yasushi Fuku},
  journal = {Cardiology research},
  year = {2026},
  month = oct,
  doi = {10.14740/cr2307},
  url = {https://europepmc.org/article/MED/42968848},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Association Between Changes in Paravalvular Leakage After Transcatheter Aortic Valve Implantation and Serum Lactate Dehydrogenase.
AU  - Akihiro Ikuta
AU  - Gakuto Bando
AU  - Satoki Oka
AU  - Shunsuke Matsushita
AU  - Naoya Inoue
AU  - Shingo Hirao
AU  - Mitsuru Abe
AU  - Kazushige Kadota
AU  - Tatsuhiko Komiya
AU  - Yasushi Fuku
PY  - 2026
DA  - 2026/10/24
JO  - Cardiology research
DO  - 10.14740/cr2307
UR  - https://europepmc.org/article/MED/42968848
AB  - Background  The association between changes in paravalvular leakage (PVL) and serum lactate dehydrogenase (LDH) levels in patients undergoing transcatheter aortic valve implantation (TAVI) is unexplored. We aimed to investigate the short-term changes in PVL after TAVI and their association with LDH elevation.Methods  A total of 550 consecutive patients underwent TAVI from 2020 to 2024. Of these, 313 receiving SAPIEN 3 (S3) or SAPIEN 3 Ultra RESILIA (S3UR) valves were included in this study. Patients were categorized into two groups based on whether their PVL severity worsened by at least one grade from immediately after the procedure to hospital discharge.Results  PVL deterioration was observed in 16.3% of patients. The incidence of moderate or greater LDH elevation was significantly higher in the PVL deterioration group than in the non-PVL deterioration group at 7 days (17.6% vs. 8.4%; P = 0.04) and 1 month (29.4% vs. 8.8%; P < 0.01) after the procedure. The area under the receiver operating characteristic (ROC) curve for predicting PVL deterioration using the sizing index (SI) was 0.84, with an optimal cut-off value of 96.5% (odds ratio (OR): 13.6; 95% confidence interval (CI): 6.55-31.1; P < 0.01). Multivariable analysis showed that an aortic valve calcium score ≥ 1,435, use of the S3UR valve, and an SI < 96.5 were independently associated with PVL deterioration.Conclusion  Early PVL deterioration after TAVI with a balloon-expandable valve may be associated with LDH elevation. These findings highlight the importance of selecting a prosthetic valve with an appropriate sizing ratio to minimize PVL deterioration after TAVI.
SN  - 1923-2829
SN  - 1923-2837
ER  -