Sex-specific Risks in Lung Cancer-Associated Thrombosis: Focus on Female Patients

Abstract

Sex and lung cancer-associated thrombosis (CAT) matter. Venous thromboembolism (VTE) is a frequent and serious complication in lung cancer, and accumulating evidence suggests that sex-related factors may influence thrombotic risk. In this review, we highlight the epidemiological, clinical, and biological specificities of women in relation to thrombotic risk in lung cancer. We explore sex-specific determinants of CAT, including host-, tumor-and treatment-related factors. Special attention is given to oncogene-addicted adenocarcinoma, particularly enriched in women and their implications for VTE risk and anticoagulation management. We also discuss the therapeutic challenges specific to female patients, including bleeding risks, drug-drug interactions with tyrosine kinase inhibitors and the need for sex-informed VTE risk stratification.

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BibTeX RIS

BibTeX

@article{geier2026sexspecific,
  title = {{Sex-specific Risks in Lung Cancer-Associated Thrombosis: Focus on Female Patients}},
  author = {Margaux Geier and Jessica Nguyen and Benjamin Auberger and Renaud Descourt and Gilles Quéré and Chloé Ntshaykolo and Estelle Dhamelincourt and Inès Peillon and François Lucia and Vincent Bourbonne and Francis Couturaud},
  journal = {Clinical and Applied Thrombosis/Hemostasis},
  year = {2026},
  month = sep,
  doi = {10.1177/10760296261472666},
  url = {https://univ-brest.hal.science/hal-05733977v1},
  note = {CC BY-NC 4.0},
}

RIS

TY  - JOUR
TI  - Sex-specific Risks in Lung Cancer-Associated Thrombosis: Focus on Female Patients
AU  - Margaux Geier
AU  - Jessica Nguyen
AU  - Benjamin Auberger
AU  - Renaud Descourt
AU  - Gilles Quéré
AU  - Chloé Ntshaykolo
AU  - Estelle Dhamelincourt
AU  - Inès Peillon
AU  - François Lucia
AU  - Vincent Bourbonne
AU  - Francis Couturaud
PY  - 2026
DA  - 2026/09/01
JO  - Clinical and Applied Thrombosis/Hemostasis
DO  - 10.1177/10760296261472666
UR  - https://univ-brest.hal.science/hal-05733977v1
AB  - Sex and lung cancer-associated thrombosis (CAT) matter. Venous thromboembolism (VTE) is a frequent and serious complication in lung cancer, and accumulating evidence suggests that sex-related factors may influence thrombotic risk. In this review, we highlight the epidemiological, clinical, and biological specificities of women in relation to thrombotic risk in lung cancer. We explore sex-specific determinants of CAT, including host-, tumor-and treatment-related factors. Special attention is given to oncogene-addicted adenocarcinoma, particularly enriched in women and their implications for VTE risk and anticoagulation management. We also discuss the therapeutic challenges specific to female patients, including bleeding risks, drug-drug interactions with tyrosine kinase inhibitors and the need for sex-informed VTE risk stratification.
SN  - 1076-0296
SN  - 1938-2723
ER  -

Abstract

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