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Peer-reviewedCC BY-NC-NDJACC. Basic to translational science

A Circulating Extracellular Vesicle-Bound Fraction of Cardiac Troponin Discriminates Myocardial Homeostasis and Disease States.

  • Jona Benjamin Krohn1
  • Dominika Bernath-Nagy2
  • Yuetong Leona Ding3
  • Melek Sükran Kalinyaprak3
  • Liliana Francois1
  • Gabriel Jakob Trauner3
  • Chiara Hess3
  • Niklas Hartmann1
  • Felix Wiedmann
  • Constanze Schmidt
  • Hugo Katus1
  • Norbert Frey1
2 more authors
  • Florian Leuschner1
  • Evangelos Giannitsis4
4 affiliations
  1. 1Department of Cardiology, Pulmonology and Angiology, University Hospital Heidelberg, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research) Partner Site Heidelberg/Mannheim, University of Heidelberg, Heidelberg, Germany.
  2. 2Department of Cardiology, Pulmonology and Angiology, University Hospital Heidelberg, Heidelberg, Germany; Heart and Vascular Centre, Semmelweis University, Budapest, Hungary.
  3. 3Department of Cardiology, Pulmonology and Angiology, University Hospital Heidelberg, Heidelberg, Germany.
  4. 4Department of Cardiology, Pulmonology and Angiology, University Hospital Heidelberg, Heidelberg, Germany. Electronic address: [email protected].
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Abstract

Transient troponin elevation is a common observation in various nonischemic cardiovascular diseases, the origin of which remains widely unknown. We hypothesized that troponins enclosed in extracellular vesicles (EVs) and released by cardiomyocytes into circulation account for distinct disease-specific compartmental troponin signatures. In vitro, hypoxic cardiomyocytes secreted EVs enriched with cardiac troponin T (cTnT). Mice after myocardial infarction showed increased blood EV concentration, and pigs under induced atrial fibrillation showed distinct EV-cTnT signatures. These specific EV-cTnT and cardiac troponin I compartmental patterns were verified in 2 patient cohorts of myocardial infarction and atrial fibrillation, introducing relative EV-cardiac troponin as a novel biomarker to discriminate cardiovascular pathologies.

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Cite

BibTeXRIS
BibTeX
@article{krohn2026circulating,
  title = {{A Circulating Extracellular Vesicle-Bound Fraction of Cardiac Troponin Discriminates Myocardial Homeostasis and Disease States.}},
  author = {Jona Benjamin Krohn and Dominika Bernath-Nagy and Yuetong Leona Ding and Melek Sükran Kalinyaprak and Liliana Francois and Gabriel Jakob Trauner and Chiara Hess and Niklas Hartmann and Felix Wiedmann and Constanze Schmidt and Hugo Katus and Norbert Frey and Florian Leuschner and Evangelos Giannitsis},
  journal = {JACC. Basic to translational science},
  year = {2026},
  month = sep,
  doi = {10.1016/j.jacbts.2026.101728},
  url = {https://europepmc.org/article/MED/42868976},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - A Circulating Extracellular Vesicle-Bound Fraction of Cardiac Troponin Discriminates Myocardial Homeostasis and Disease States.
AU  - Jona Benjamin Krohn
AU  - Dominika Bernath-Nagy
AU  - Yuetong Leona Ding
AU  - Melek Sükran Kalinyaprak
AU  - Liliana Francois
AU  - Gabriel Jakob Trauner
AU  - Chiara Hess
AU  - Niklas Hartmann
AU  - Felix Wiedmann
AU  - Constanze Schmidt
AU  - Hugo Katus
AU  - Norbert Frey
AU  - Florian Leuschner
AU  - Evangelos Giannitsis
PY  - 2026
DA  - 2026/09/22
JO  - JACC. Basic to translational science
DO  - 10.1016/j.jacbts.2026.101728
UR  - https://europepmc.org/article/MED/42868976
AB  - Transient troponin elevation is a common observation in various nonischemic cardiovascular diseases, the origin of which remains widely unknown. We hypothesized that troponins enclosed in extracellular vesicles (EVs) and released by cardiomyocytes into circulation account for distinct disease-specific compartmental troponin signatures. In vitro, hypoxic cardiomyocytes secreted EVs enriched with cardiac troponin T (cTnT). Mice after myocardial infarction showed increased blood EV concentration, and pigs under induced atrial fibrillation showed distinct EV-cTnT signatures. These specific EV-cTnT and cardiac troponin I compartmental patterns were verified in 2 patient cohorts of myocardial infarction and atrial fibrillation, introducing relative EV-cardiac troponin as a novel biomarker to discriminate cardiovascular pathologies.
SN  - 2452-302X
ER  -