Therapeutic delivery systems need to focus on cellular precision to target neurodegeneration

Abstract

The central problem when delivering drugs to the brain is no longer crossing the blood–brain barrier, but delivering therapeutics to the right cells, in the right regions to target neurodegeneration, within a dynamically changing neurovascular unit.

Crossing the blood–brain barrier is no longer a problem for delivering therapeutics to the brain. This Perspective argues that the main challenge is now how to deliver therapeutics to the right cells, in the right regions to target neurodegeneration, within a dynamically changing neurovascular unit.

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BibTeX RIS

BibTeX

@article{gupta2026therapeutic,
  title = {{Therapeutic delivery systems need to focus on cellular precision to target neurodegeneration}},
  author = {Lavanya Gupta and Sinem Agilkaya and Kim Susann Keller and Ebru Ercan-Herbst},
  journal = {PLOS Biology},
  year = {2026},
  month = oct,
  doi = {10.1371/journal.pbio.3004049},
  url = {https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3004049},
  note = {CC BY 4.0},
}

RIS

TY  - JOUR
TI  - Therapeutic delivery systems need to focus on cellular precision to target neurodegeneration
AU  - Lavanya Gupta
AU  - Sinem Agilkaya
AU  - Kim Susann Keller
AU  - Ebru Ercan-Herbst
PY  - 2026
DA  - 2026/10/26
JO  - PLOS Biology
DO  - 10.1371/journal.pbio.3004049
UR  - https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3004049
AB  - The central problem when delivering drugs to the brain is no longer crossing the blood–brain barrier, but delivering therapeutics to the right cells, in the right regions to target neurodegeneration, within a dynamically changing neurovascular unit.  Crossing the blood–brain barrier is no longer a problem for delivering therapeutics to the brain. This Perspective argues that the main challenge is now how to deliver therapeutics to the right cells, in the right regions to target neurodegeneration, within a dynamically changing neurovascular unit.
SN  - 1545-7885
SN  - 1544-9173
ER  -

Abstract

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