Recent advances in the total synthesis of limonoid natural products: a decade of progress.
- 1College of Life Sciences, Zhuhai College of Science and Technology Zhuhai 519041 China [email protected] [email protected].
- 2State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School Shenzhen 518055 China.
Abstract
Limonoid natural products are highly oxygenated tetranortriterpenoids with broad-spectrum biological activities, yet their compact polycyclic frameworks and multiple contiguous stereocentres render them formidable targets for total synthesis. This review summarizes recent advances in the total synthesis of limonoid natural products from 2017 to 2026. The discussion is organised by the structural classification of limonoids, covering ring-intact limonoids, ring-seco limonoids (including ring C-seco, D-seco, A,D-seco, and B,D-seco types), rearranged limonoids, and limonoid alkaloids. Emphasis is placed on key strategic disconnections and the emergence of modern methodologies such as photoredox catalysis, C-H activation, metal-hydrogen-atom-transfer-mediated radical cyclisation, and chemoenzymatic approaches.
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BibTeX
@article{chen2026recent,
title = {{Recent advances in the total synthesis of limonoid natural products: a decade of progress.}},
author = {Wei Chen and Xiaobo Zhou and Dongsheng Yang},
journal = {RSC advances},
year = {2026},
month = oct,
doi = {10.1039/d6ra08819h},
url = {https://europepmc.org/article/MED/42924226},
note = {CC BY},
}
RIS
TY - JOUR
TI - Recent advances in the total synthesis of limonoid natural products: a decade of progress.
AU - Wei Chen
AU - Xiaobo Zhou
AU - Dongsheng Yang
PY - 2026
DA - 2026/10/22
JO - RSC advances
DO - 10.1039/d6ra08819h
UR - https://europepmc.org/article/MED/42924226
AB - Limonoid natural products are highly oxygenated tetranortriterpenoids with broad-spectrum biological activities, yet their compact polycyclic frameworks and multiple contiguous stereocentres render them formidable targets for total synthesis. This review summarizes recent advances in the total synthesis of limonoid natural products from 2017 to 2026. The discussion is organised by the structural classification of limonoids, covering ring-intact limonoids, ring-seco limonoids (including ring C-seco, D-seco, A,D-seco, and B,D-seco types), rearranged limonoids, and limonoid alkaloids. Emphasis is placed on key strategic disconnections and the emergence of modern methodologies such as photoredox catalysis, C-H activation, metal-hydrogen-atom-transfer-mediated radical cyclisation, and chemoenzymatic approaches.
SN - 2046-2069
ER -