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Peer-reviewedCC BY 4.0Nature Neuroscience

Spatial, temporal and Notch determination of terminal selector expression controls neuronal cell fate in the Drosophila optic lobe

  • Félix Simon
  • Isabel Holguera
  • Yen-Chung Chen
  • Jennifer Malin
  • Priscilla Valentino
  • Claire Njoo-Deplante
  • Rana Naja El-Danaf
  • Katarina Kapuralin
  • Ted Erclik
  • Nikolaos Konstantinides
  • Mehmet Neset Özel
  • Claude Desplan
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Abstract

In the medulla of the Drosophila optic lobe, the identity of each neuronal type is specified in progenitors and newborn neurons via the integration of temporal, spatial, and Notch-driven patterning mechanisms. This identity is maintained in differentiating and adult neurons by the continuous expression of neuronal type-specific combinations of transcription factors called terminal selectors, which are thought to control all neuronal type-specific features. How the patterning mechanisms establish terminal selector expression is unknown. Here, we have used single-cell mRNA-sequencing to characterize the spatial origins of medulla neurons. Combined to our previous characterization of their temporal and Notch origins, this allowed us to identify correlations between patterning information, terminal selector expression and neuronal features. Our results suggest that different subsets of the patterning information accessible to a given neuronal type control the expression of each of its terminal selectors and of modules of terminal features, including neurotransmitter identity.

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Cite

BibTeXRIS
BibTeX
@article{simon2026spatial,
  title = {{Spatial, temporal and Notch determination of terminal selector expression controls neuronal cell fate in the Drosophila optic lobe}},
  author = {Félix Simon and Isabel Holguera and Yen-Chung Chen and Jennifer Malin and Priscilla Valentino and Claire Njoo-Deplante and Rana Naja El-Danaf and Katarina Kapuralin and Ted Erclik and Nikolaos Konstantinides and Mehmet Neset Özel and Claude Desplan},
  journal = {Nature Neuroscience},
  year = {2026},
  month = sep,
  doi = {10.1038/s41593-026-02256-6},
  url = {https://hal.science/hal-05762880v1},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Spatial, temporal and Notch determination of terminal selector expression controls neuronal cell fate in the Drosophila optic lobe
AU  - Félix Simon
AU  - Isabel Holguera
AU  - Yen-Chung Chen
AU  - Jennifer Malin
AU  - Priscilla Valentino
AU  - Claire Njoo-Deplante
AU  - Rana Naja El-Danaf
AU  - Katarina Kapuralin
AU  - Ted Erclik
AU  - Nikolaos Konstantinides
AU  - Mehmet Neset Özel
AU  - Claude Desplan
PY  - 2026
DA  - 2026/09/24
JO  - Nature Neuroscience
DO  - 10.1038/s41593-026-02256-6
UR  - https://hal.science/hal-05762880v1
AB  - In the medulla of the Drosophila optic lobe, the identity of each neuronal type is specified in progenitors and newborn neurons via the integration of temporal, spatial, and Notch-driven patterning mechanisms. This identity is maintained in differentiating and adult neurons by the continuous expression of neuronal type-specific combinations of transcription factors called terminal selectors, which are thought to control all neuronal type-specific features. How the patterning mechanisms establish terminal selector expression is unknown. Here, we have used single-cell mRNA-sequencing to characterize the spatial origins of medulla neurons. Combined to our previous characterization of their temporal and Notch origins, this allowed us to identify correlations between patterning information, terminal selector expression and neuronal features. Our results suggest that different subsets of the patterning information accessible to a given neuronal type control the expression of each of its terminal selectors and of modules of terminal features, including neurotransmitter identity.
SN  - 1097-6256
SN  - 1546-1726
ER  -