The GLIDE Score: One-Year Outcomes Following Tricuspid Transcatheter Edge-to-Edge Repair
7 affiliations
- 1Department of General and Interventional Cardiology/Angiology, Ruhr University Bochum, Heart and Diabetes Center NRW, Bad Oeynhausen, Germany.
- 2Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
- 3Department for Internal Medicine III, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
- 4Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
- 5Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls Universität Tübingen, Tübingen, Germany.
- 6Department of Cardiology, Inselspital, Bern, Switzerland.
- 7Graduate School for Health Sciences, University of Bern, Switzerland.
Abstract
Background: The GLIDE score is a 5-point imaging-based tool to predict residual tricuspid regurgitation (TR) after tricuspid transcatheter edge-to-edge repair (T-TEER). Lower residual TR is associated with better prognosis, but long-term associations between GLIDE score and outcomes are uncertain. Methods: We performed an analysis of a multinational registry of patients undergoing T-TEER for severe or greater TR from January 2017 to November 2022. GLIDE scores were assessed using preprocedural transesophageal echocardiography. The primary endpoint was a composite of all-cause mortality or heart failure hospitalization (HFH) at 1 year, and the secondary endpoints included TR grade of moderate or less at 1 year. Results: In 336 patients (81 [interquartile range 77–84] years; 44.6% male, TRI-SCORE 5 [interquartile range 4–6]), survival and HFH follow-up at 1 year was available in 90.5%. One-year mortality was 15.8%. The GLIDE score was significantly associated with the combined primary endpoint (hazard ratio: 1.20; 95% CI 1.03–1.40; p = 0.019), even after adjustment for TRI-SCORE. Freedom from death or HFH was significantly higher among patients with GLIDE scores ≤1 compared to those ≥2 ( p = 0.032). Of the 251 1-year survivors, follow-up echocardiography was available in 170 (68%). The GLIDE score predicted 1-year TR severity (area under the receiver operating characteristic curve: 0.73; 95% CI 0.65–0.81), with moderate or less residual TR achieved in 80.6%, 54.9%, and 18.8% of patients with GLIDE scores of 0–1, 2–3, and ≥4, respectively. Conclusions: The GLIDE score is associated with 1-year survival and HFH after T-TEER as well as ≤ moderate TR.
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BibTeX
@article{rudolph2026glide,
title = {{The GLIDE Score: One-Year Outcomes Following Tricuspid Transcatheter Edge-to-Edge Repair}},
author = {Felix Rudolph and Akhil Narang and Maria I Körber and Kai P Friedrichs and Johannes Kirchner and Maria Ivannikova and Carolina Esperanca Clara Göttsche and Jan Althoff and Paul Cremer and Peter Luedike and Tanja K Rudolph and Tobias Geisler and Mohammad Kassar and Max Potratz and Tienush Rassaf and Roman Pfister and Fabien Praz and Volker Rudolph and Muhammed Gerçek and Charles J Davidson},
journal = {Structural Heart},
year = {2026},
month = jul,
doi = {10.1016/j.shj.2026.101096},
url = {https://doi.org/10.1016/j.shj.2026.101096},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - The GLIDE Score: One-Year Outcomes Following Tricuspid Transcatheter Edge-to-Edge Repair
AU - Felix Rudolph
AU - Akhil Narang
AU - Maria I Körber
AU - Kai P Friedrichs
AU - Johannes Kirchner
AU - Maria Ivannikova
AU - Carolina Esperanca Clara Göttsche
AU - Jan Althoff
AU - Paul Cremer
AU - Peter Luedike
AU - Tanja K Rudolph
AU - Tobias Geisler
AU - Mohammad Kassar
AU - Max Potratz
AU - Tienush Rassaf
AU - Roman Pfister
AU - Fabien Praz
AU - Volker Rudolph
AU - Muhammed Gerçek
AU - Charles J Davidson
PY - 2026
DA - 2026/07/21
JO - Structural Heart
DO - 10.1016/j.shj.2026.101096
UR - https://doi.org/10.1016/j.shj.2026.101096
AB - Background: The GLIDE score is a 5-point imaging-based tool to predict residual tricuspid regurgitation (TR) after tricuspid transcatheter edge-to-edge repair (T-TEER). Lower residual TR is associated with better prognosis, but long-term associations between GLIDE score and outcomes are uncertain. Methods: We performed an analysis of a multinational registry of patients undergoing T-TEER for severe or greater TR from January 2017 to November 2022. GLIDE scores were assessed using preprocedural transesophageal echocardiography. The primary endpoint was a composite of all-cause mortality or heart failure hospitalization (HFH) at 1 year, and the secondary endpoints included TR grade of moderate or less at 1 year. Results: In 336 patients (81 [interquartile range 77–84] years; 44.6% male, TRI-SCORE 5 [interquartile range 4–6]), survival and HFH follow-up at 1 year was available in 90.5%. One-year mortality was 15.8%. The GLIDE score was significantly associated with the combined primary endpoint (hazard ratio: 1.20; 95% CI 1.03–1.40; p = 0.019), even after adjustment for TRI-SCORE. Freedom from death or HFH was significantly higher among patients with GLIDE scores ≤1 compared to those ≥2 ( p = 0.032). Of the 251 1-year survivors, follow-up echocardiography was available in 170 (68%). The GLIDE score predicted 1-year TR severity (area under the receiver operating characteristic curve: 0.73; 95% CI 0.65–0.81), with moderate or less residual TR achieved in 80.6%, 54.9%, and 18.8% of patients with GLIDE scores of 0–1, 2–3, and ≥4, respectively. Conclusions: The GLIDE score is associated with 1-year survival and HFH after T-TEER as well as ≤ moderate TR.
SN - 2474-8706
SN - 2474-8714
ER -