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Peer-reviewedCC BY-NC 4.0International Journal of Women's Health

Are Oocyte Maturation Rates Associated with LH Levels in GnRH Antagonist Cycles Using GnRH Agonist Triggering?

  • Chen Nahshon1,2
  • Efrat Yanai1,2
  • Nadav Cohen1,2
  • Wisam Assaf1,2
  • Nir Kugelman1,2
  • Sivan Skvirsky1,2
  • Shirly Lahav-Baratz1
  • Idit Blais1
  • Galia Oron1,2
  1. 1Department of Obstetrics and Gynecology, Lady Davis Carmel Medical Center, Haifa, Israel
  2. 2The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
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Abstract

Objective: To evaluate whether oocyte maturation rates are influenced by basal LH levels, LH levels on the day of trigger, or the magnitude of LH decline during controlled ovarian stimulation in GnRH antagonist cycles using an agonist trigger.

Methods: This retrospective study included patients treated at our IVF unit between 2014 and 2024. All 432 GnRH antagonist cycles triggered with GnRH agonist were analyzed. The primary outcomes were the associations between basal LH levels and the absolute number of oocytes retrieved, oocyte maturation rate, and fertilization rate. Fertilization analyses were restricted to cycles not performed for fertility preservation.

Results: Basal LH levels were not associated with the number of oocytes retrieved, maturation rate, or fertilization rate in multivariable analyses. LH levels on the trigger day were not associated with retrieval, maturation, or fertilization outcomes. Similarly, the percentage decline in LH levels during stimulation was not associated with cycle outcomes.

Conclusion: Pre-trigger LH measurements, including basal LH, trigger-day LH, and LH decline during stimulation, were not significantly associated with oocyte retrieval, maturation, or fertilization outcomes. These findings suggest limited predictive value of pre-trigger LH measurements in this population, although a threshold effect at very low LH levels cannot be excluded.

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Cite

BibTeXRIS
BibTeX
@article{nahshon2026oocyte,
  title = {{Are Oocyte Maturation Rates Associated with LH Levels in GnRH Antagonist Cycles Using GnRH Agonist Triggering?}},
  author = {Chen Nahshon and Efrat Yanai and Nadav Cohen and Wisam Assaf and Nir Kugelman and Sivan Skvirsky and Shirly Lahav-Baratz and Idit Blais and Galia Oron},
  journal = {International Journal of Women's Health},
  year = {2026},
  month = oct,
  doi = {10.2147/ijwh.s630235},
  url = {https://doi.org/10.2147/ijwh.s630235},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - Are Oocyte Maturation Rates Associated with LH Levels in GnRH Antagonist Cycles Using GnRH Agonist Triggering?
AU  - Chen Nahshon
AU  - Efrat Yanai
AU  - Nadav Cohen
AU  - Wisam Assaf
AU  - Nir Kugelman
AU  - Sivan Skvirsky
AU  - Shirly Lahav-Baratz
AU  - Idit Blais
AU  - Galia Oron
PY  - 2026
DA  - 2026/10/30
JO  - International Journal of Women's Health
DO  - 10.2147/ijwh.s630235
UR  - https://doi.org/10.2147/ijwh.s630235
AB  - Objective: To evaluate whether oocyte maturation rates are influenced by basal LH levels, LH levels on the day of trigger, or the magnitude of LH decline during controlled ovarian stimulation in GnRH antagonist cycles using an agonist trigger.  Methods: This retrospective study included patients treated at our IVF unit between 2014 and 2024. All 432 GnRH antagonist cycles triggered with GnRH agonist were analyzed. The primary outcomes were the associations between basal LH levels and the absolute number of oocytes retrieved, oocyte maturation rate, and fertilization rate. Fertilization analyses were restricted to cycles not performed for fertility preservation.  Results: Basal LH levels were not associated with the number of oocytes retrieved, maturation rate, or fertilization rate in multivariable analyses. LH levels on the trigger day were not associated with retrieval, maturation, or fertilization outcomes. Similarly, the percentage decline in LH levels during stimulation was not associated with cycle outcomes.  Conclusion: Pre-trigger LH measurements, including basal LH, trigger-day LH, and LH decline during stimulation, were not significantly associated with oocyte retrieval, maturation, or fertilization outcomes. These findings suggest limited predictive value of pre-trigger LH measurements in this population, although a threshold effect at very low LH levels cannot be excluded.
SN  - 1179-1411
ER  -