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Peer-reviewedCC BYAmerican journal of physiology. Regulatory, integrative and comparative physiology

Diet Composition Modifies Cardiometabolic Phenotype Development in the 4-Vinylcyclohexene Dioxide (VCD) Ovarian Failure Model of Menopause

  • Natalia M. Mathieu1,2
  • Samuel B.R. Lawton1,3
  • Margaret M. Dorrington1,2
  • Connie C. Grobe4
  • Valerie W. Hole1
  • Kelsey K. Wackman1
  • Henry Bordas-Murphy5
  • Julie K. Freed1,2,5
  • Jeffrey L. Segar1,2,4
  • Pablo Nakagawa1,2
  • Curt D. Sigmund1,2
  • Gary C. Mouradian1,2
2 more authors
  • Justin L. Grobe1,2,6,7
  • John J. Reho1,6
7 affiliations
  1. 1Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA
  2. 2Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI, USA
  3. 3Medical Scientist Training Program, Medical College of Wisconsin, Milwaukee, WI, USA
  4. 4Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA
  5. 5Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA
  6. 6Comprehensive Rodent Metabolic Phenotyping Core, Medical College of Wisconsin, Milwaukee, WI, USA
  7. 7Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, USA
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Abstract

This study demonstrates that the metabolic phenotypes induced by 4-vinylcyclohexene diepoxide (VCD)-induced ovarian failure in rodents, used as an experimental model of menopause, strongly depend upon diet formulation. VCD-treated mice fed a corn/soy-based diet (PicoLab 5L0D) exhibited suppressed resting and total energy expenditures and increased adiposity, which parallels effects of menopause documented in humans. In contrast, VCD failed to induce such phenotypes in mice fed a wheat/corn-based diet (Inotiv 2920x).

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Cite

BibTeXRIS
BibTeX
@article{mathieu2026diet,
  title = {{Diet Composition Modifies Cardiometabolic Phenotype Development in the 4-Vinylcyclohexene Dioxide (VCD) Ovarian Failure Model of Menopause}},
  author = {Natalia M. Mathieu and Samuel B.R. Lawton and Margaret M. Dorrington and Connie C. Grobe and Valerie W. Hole and Kelsey K. Wackman and Henry Bordas-Murphy and Julie K. Freed and Jeffrey L. Segar and Pablo Nakagawa and Curt D. Sigmund and Gary C. Mouradian and Justin L. Grobe and John J. Reho},
  journal = {American journal of physiology. Regulatory, integrative and comparative physiology},
  year = {2026},
  month = oct,
  doi = {10.1152/ajpregu.00321.2025},
  url = {https://doi.org/10.1152/ajpregu.00321.2025},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Diet Composition Modifies Cardiometabolic Phenotype Development in the 4-Vinylcyclohexene Dioxide (VCD) Ovarian Failure Model of Menopause
AU  - Natalia M. Mathieu
AU  - Samuel B.R. Lawton
AU  - Margaret M. Dorrington
AU  - Connie C. Grobe
AU  - Valerie W. Hole
AU  - Kelsey K. Wackman
AU  - Henry Bordas-Murphy
AU  - Julie K. Freed
AU  - Jeffrey L. Segar
AU  - Pablo Nakagawa
AU  - Curt D. Sigmund
AU  - Gary C. Mouradian
AU  - Justin L. Grobe
AU  - John J. Reho
PY  - 2026
DA  - 2026/10/01
JO  - American journal of physiology. Regulatory, integrative and comparative physiology
DO  - 10.1152/ajpregu.00321.2025
UR  - https://doi.org/10.1152/ajpregu.00321.2025
AB  - This study demonstrates that the metabolic phenotypes induced by 4-vinylcyclohexene diepoxide (VCD)-induced ovarian failure in rodents, used as an experimental model of menopause, strongly depend upon diet formulation. VCD-treated mice fed a corn/soy-based diet (PicoLab 5L0D) exhibited suppressed resting and total energy expenditures and increased adiposity, which parallels effects of menopause documented in humans. In contrast, VCD failed to induce such phenotypes in mice fed a wheat/corn-based diet (Inotiv 2920x).
SN  - 0363-6119
SN  - 1522-1490
ER  -