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Peer-reviewedCC BYBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

Thoraco-laparoscopic versus open McKeown esophagectomy for esophageal cancer: comparative outcomes on inflammatory response and coagulation function

  • Zhengqiao Wang1
  • Renquan Zhang1
  1. 1Department of General Thoracic Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China
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Abstract

We aimed to unravel the efficacy of thoraco-laparoscopic combined McKeown esophagectomy for esophageal cancer and its impact on inflammatory response and coagulation function. We retrospectively analyzed 108 esophageal cancer patients, divided into thoraco-laparoscopic (TLE) and open esophagectomy (OE) groups. Observed indicators included surgical parameters (operative time, blood loss, ICU and hospital stays), inflammatory markers [white blood cell (WBC), neutrophil percentage (NEUT%), lymphocyte percentage (LYMPH%), platelet (PLT)], coagulation profiles [prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (APTT), fibrinogen (FIB), D-dimer (D-D)], complications, and 1-year disease-free survival. The TLE group demonstrated reduced intraoperative blood loss, shorter ICU and total hospital stays, and lower complication rates than the OE group (P<0.05). Postoperative inflammatory and coagulation profiles also differed, with TLE showing lower WBC (11.35±2.58 vs 12.48±2.41 109/L), NEUT% (72.28±6.62 vs 79.41±6.94%), PLT (233.87±19.62 vs 245.56±22.79 109/L), PT (11.41±0.79 vs 12.00±1.05 s), APTT (26.70±3.60 vs 28.83±3.08 s), and INR (0.90±0.07 vs 0.95±0.10), but higher LYMPH% (21.80±4.06 vs 19.52±4.16 %), D-D (348.89±37.92 vs 315.27±36.74 μg/L), and FIB (3.95±0.56 vs 3.71±0.51 g/L) levels than the OE group (P<0.05). TLE was an effective and reliable approach associated with fewer complications and comparable one-year oncologic outcomes to open surgery, though its effects on coagulation parameters warrant closer clinical monitoring.

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Cite

BibTeXRIS
BibTeX
@article{wang2026thoracolaparoscopic,
  title = {{Thoraco-laparoscopic versus open McKeown esophagectomy for esophageal cancer: comparative outcomes on inflammatory response and coagulation function}},
  author = {Zhengqiao Wang and Renquan Zhang},
  journal = {Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas},
  year = {2026},
  month = oct,
  doi = {10.1590/1414-431x2026e15544},
  url = {https://europepmc.org/article/PMC/PMC13721996},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Thoraco-laparoscopic versus open McKeown esophagectomy for esophageal cancer: comparative outcomes on inflammatory response and coagulation function
AU  - Zhengqiao Wang
AU  - Renquan Zhang
PY  - 2026
DA  - 2026/10/01
JO  - Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
DO  - 10.1590/1414-431x2026e15544
UR  - https://europepmc.org/article/PMC/PMC13721996
AB  - We aimed to unravel the efficacy of thoraco-laparoscopic combined McKeown esophagectomy for esophageal cancer and its impact on inflammatory response and coagulation function. We retrospectively analyzed 108 esophageal cancer patients, divided into thoraco-laparoscopic (TLE) and open esophagectomy (OE) groups. Observed indicators included surgical parameters (operative time, blood loss, ICU and hospital stays), inflammatory markers [white blood cell (WBC), neutrophil percentage (NEUT%), lymphocyte percentage (LYMPH%), platelet (PLT)], coagulation profiles [prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (APTT), fibrinogen (FIB), D-dimer (D-D)], complications, and 1-year disease-free survival. The TLE group demonstrated reduced intraoperative blood loss, shorter ICU and total hospital stays, and lower complication rates than the OE group (P<0.05). Postoperative inflammatory and coagulation profiles also differed, with TLE showing lower WBC (11.35±2.58 vs 12.48±2.41 109/L), NEUT% (72.28±6.62 vs 79.41±6.94%), PLT (233.87±19.62 vs 245.56±22.79 109/L), PT (11.41±0.79 vs 12.00±1.05 s), APTT (26.70±3.60 vs 28.83±3.08 s), and INR (0.90±0.07 vs 0.95±0.10), but higher LYMPH% (21.80±4.06 vs 19.52±4.16 %), D-D (348.89±37.92 vs 315.27±36.74 μg/L), and FIB (3.95±0.56 vs 3.71±0.51 g/L) levels than the OE group (P<0.05). TLE was an effective and reliable approach associated with fewer complications and comparable one-year oncologic outcomes to open surgery, though its effects on coagulation parameters warrant closer clinical monitoring.
SN  - 0100-879X
SN  - 1414-431X
ER  -