The Prevalence and Clinical Characteristics of Atrial Fibrillation and Reflux Esophagitis Among Individuals Undergoing Health Checkups
Abstract
Objective To examine the association between atrial fibrillation (AF) and reflux esophagitis (RE).Methods A total of 5,205 adults (3,262 men, 1,943 women; mean age, 54.9±9.8 years) who underwent esophagogastroduodenoscopy (EGD) as part of a routine health checkup were enrolled in this study. AF was defined as AF detected on electrocardiography during the checkup and/or a documented history of the condition. RE was assessed endoscopically according to the Los Angeles classification. The smoking history, habitual alcohol consumption, and use of acid-suppressive agents were also assessed.Results AF was observed in 36 participants (0.7%). Compared with those without AF, participants with AF were more likely to be male, older, have a higher body mass index, and have a history of smoking and acid-suppressive agent use. After excluding participants receiving acid-suppressive medications, RE was significantly more prevalent in patients with AF than in those without AF (39.1% vs. 22.0%, p=0.049). The prevalence of AF was 0.9% among patients with RE and 0.4% among those without RE. However, multiple logistic regression analysis indicated that RE was not independently associated with AF after adjusting for sex, age, and other clinical factors.Conclusion AF may be associated with RE in individuals undergoing routine health checkups. However, this association was attenuated after adjustment for sex, age, and other clinical factors, suggesting that it may be largely explained by shared confounding factors.
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BibTeX
@article{adachi2026prevalence,
title = {{The Prevalence and Clinical Characteristics of Atrial Fibrillation and Reflux Esophagitis Among Individuals Undergoing Health Checkups}},
author = {Kyoichi Adachi and Norihisa Ishimura and Yuko Miki and Kanako Kishi and Utae Sakamoto and Eiko Okimoto and Yuko Matsubara and Madoka Furuta and Nobuhide Watanabe and Shunji Ishihara},
journal = {Internal Medicine},
year = {2026},
month = oct,
doi = {10.2169/internalmedicine.8127-26},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_8127-26/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - The Prevalence and Clinical Characteristics of Atrial Fibrillation and Reflux Esophagitis Among Individuals Undergoing Health Checkups
AU - Kyoichi Adachi
AU - Norihisa Ishimura
AU - Yuko Miki
AU - Kanako Kishi
AU - Utae Sakamoto
AU - Eiko Okimoto
AU - Yuko Matsubara
AU - Madoka Furuta
AU - Nobuhide Watanabe
AU - Shunji Ishihara
PY - 2026
DA - 2026/10/15
JO - Internal Medicine
DO - 10.2169/internalmedicine.8127-26
UR - https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_8127-26/_article
AB - Objective To examine the association between atrial fibrillation (AF) and reflux esophagitis (RE).Methods A total of 5,205 adults (3,262 men, 1,943 women; mean age, 54.9±9.8 years) who underwent esophagogastroduodenoscopy (EGD) as part of a routine health checkup were enrolled in this study. AF was defined as AF detected on electrocardiography during the checkup and/or a documented history of the condition. RE was assessed endoscopically according to the Los Angeles classification. The smoking history, habitual alcohol consumption, and use of acid-suppressive agents were also assessed.Results AF was observed in 36 participants (0.7%). Compared with those without AF, participants with AF were more likely to be male, older, have a higher body mass index, and have a history of smoking and acid-suppressive agent use. After excluding participants receiving acid-suppressive medications, RE was significantly more prevalent in patients with AF than in those without AF (39.1% vs. 22.0%, p=0.049). The prevalence of AF was 0.9% among patients with RE and 0.4% among those without RE. However, multiple logistic regression analysis indicated that RE was not independently associated with AF after adjusting for sex, age, and other clinical factors.Conclusion AF may be associated with RE in individuals undergoing routine health checkups. However, this association was attenuated after adjustment for sex, age, and other clinical factors, suggesting that it may be largely explained by shared confounding factors.
SN - 1349-7235
SN - 0918-2918
ER -